{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:11:01Z","timestamp":1791263461093,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T00:00:00Z","timestamp":1417996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2015,5]]},"abstract":"\n Background<\/jats:title>\n \n Possible transfusion\u2010related acute lung injury (p\n TRALI<\/jats:styled-content>\n ) cases by definition have a clear temporal relationship to an alternative recipient risk factor for acute respiratory distress syndrome (\n ARDS<\/jats:styled-content>\n ). We questioned whether transfusion factors are important for the development of p\n TRALI<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Study Design and Methods<\/jats:title>\n \n In this nested case\u2010control study, we prospectively identified 145 consecutive patients with p\n TRALI<\/jats:styled-content>\n and randomly selected 163 transfused controls over a 4\u2010year period at the\n U<\/jats:styled-content>\n niversity of\n C<\/jats:styled-content>\n alifornia at\n S<\/jats:styled-content>\n an\n F<\/jats:styled-content>\n rancisco and the\n M<\/jats:styled-content>\n ayo\n C<\/jats:styled-content>\n linic (\n R<\/jats:styled-content>\n ochester,\n M<\/jats:styled-content>\n innesota).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n For p\n TRALI<\/jats:styled-content>\n , we found evidence against transfusion being important: receipt of plasma from female donors (odds ratio [\n OR<\/jats:styled-content>\n ], 0.82; 95% confidence interval [\n CI<\/jats:styled-content>\n ], 0.29\u20102.3; p\u2009=\u20090.70), total number of units transfused (\n OR<\/jats:styled-content>\n , 0.99; 95%\n CI<\/jats:styled-content>\n , 0.89\u20101.10; p\u2009=\u20090.86), and number of red blood cell and whole blood units transfused (\n OR<\/jats:styled-content>\n , 0.78; 95%\n CI<\/jats:styled-content>\n , 0.59\u20101.03; p\u2009=\u20090.079). In contrast, we found that risk for p\n TRALI<\/jats:styled-content>\n was associated with additional recipient factors: chronic alcohol abuse (\n OR<\/jats:styled-content>\n , 12.5; 95%\n CI<\/jats:styled-content>\n , 2.8\u201055; p\u2009<\u20090.001), current smoker (\n OR<\/jats:styled-content>\n , 4.2; 95%\n CI<\/jats:styled-content>\n , 1.67\u201010.8; p\u2009=\u20090.0024), shock before transfusion (\n OR<\/jats:styled-content>\n , 4.6; 95%\n CI<\/jats:styled-content>\n , 2.0\u201010.7; p\u2009<\u20090.001), and positive fluid balance before transfusion (\n OR<\/jats:styled-content>\n , 1.32\/\n L<\/jats:styled-content>\n ; 95%\n CI<\/jats:styled-content>\n , 1.20\u20101.44; p\u2009<\u20090.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Recipient risk factors for\n ARDS<\/jats:styled-content>\n rather than transfusion risk factors predominate in p\n TRALI<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/trf.12954","type":"journal-article","created":{"date-parts":[[2014,12,13]],"date-time":"2014-12-13T06:06:31Z","timestamp":1418450791000},"page":"947-952","source":"Crossref","is-referenced-by-count":41,"title":["Recipient clinical risk factors predominate in possible transfusion\u2010related acute lung injury"],"prefix":"10.1111","volume":"55","author":[{"given":"Pearl","family":"Toy","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine University of California at San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bacchetti","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of California at San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Grimes","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of California at San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ognjen","family":"Gajic","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward L.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine University of California at San Francisco San Francisco California"},{"name":"Blood Systems Research Institute San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Winters","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Gropper","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care University of California at San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf D.","family":"Hubmayr","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Matthay","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California at San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Koenigsberg","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine University of California at San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deanna C.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine University of California at San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora V.","family":"Hirschler","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine University of California at San Francisco San Francisco California"},{"name":"Blood Centers of the Pacific San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford A.","family":"Lowell","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine University of California at San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy M.","family":"Schuller","sequence":"additional","affiliation":[{"name":"American Red Cross Neutrophil Reference Laboratory North Central Blood Services St Paul Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish J.","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0526-2088","authenticated-orcid":false,"given":"Philip J.","family":"Norris","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine University of California at San Francisco San Francisco California"},{"name":"Blood Systems Research Institute San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Mair","sequence":"additional","affiliation":[{"name":"American Red Cross Neutrophil Reference Laboratory North Central Blood Services St Paul Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Sanchez Rosen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine University of California at San Francisco San Francisco California"},{"name":"Blood Systems Research Institute San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Looney","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California at San Francisco San Francisco California"},{"name":"Department of Laboratory Medicine University of California at San Francisco San Francisco 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