{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:49:01Z","timestamp":1773157741078,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,3,21]],"date-time":"2015-03-21T00:00:00Z","timestamp":1426896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"SCANDAT2 database was made possible through grants from the Swedish Research Council","award":["2011-30405"],"award-info":[{"award-number":["2011-30405"]}]},{"name":"SCANDAT2 database was made possible through grants from the Swedish Research Council","award":["2007-7469"],"award-info":[{"award-number":["2007-7469"]}]},{"DOI":"10.13039\/501100003793","name":"Swedish Heart-Lung Foundation","doi-asserted-by":"crossref","award":["20090710"],"award-info":[{"award-number":["20090710"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003748","name":"Swedish Society for Medical Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003748","id-type":"DOI","asserted-by":"crossref"}]},{"name":"US National, Heart, Lung, and Blood Institute Danish Council for Independent Research","award":["2009B026"],"award-info":[{"award-number":["2009B026"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Voluntary blood donation is believed to be mostly motivated by altruism. Because studies have suggested that altruistic personality is determined by both genetic and environmental factors, we speculated that willingness to donate blood could also be governed by constitutional factors. This hypothesis was tested in a study among Danish twins.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>The nationwide Danish Twin Register, which is virtually complete for all twins born since 1968, was linked with Danish portion of the Scandinavian Donation and Transfusion (SCANDAT) Database, which includes information on all active Danish blood donors from 2002 to 2012, to establish blood donor status for Danish twins, who at age 17 years became eligible for donation in 2002 or later. Casewise concordance in monozygotic (MZ) and dizygotic (DZ) twins were presented and heritability was estimated in Mx by variance component analysis in a liability threshold model.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 274 MZ and 484 same\u2010sex DZ twins age 17 to 27 years were identified as donors in SCANDAT. There was no difference between MZ and DZ twins with regard to age at first donation or number of donations. Casewise concordance rates were 0.61 (95% confidence interval [CI], 0.56\u20100.67) and 0.41 (95% CI, 0.36\u20100.47) in MZ and DZ twin pairs, respectively. Heritability analysis using the ACE model found that additive genetic and shared environmental effects accounted for 0.53 (95% CI, 0.33\u20100.73) and 0.28 (95% CI, 0.10\u20100.45) of the variance in the motivation to donate blood, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Becoming a volunteer blood donor is determined by both genetic and environmental factors shared within families.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13086","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T15:27:17Z","timestamp":1427210837000},"page":"2169-2174","source":"Crossref","is-referenced-by-count":12,"title":["The heritability of blood donation: a population\u2010based nationwide twin study"],"prefix":"10.1111","volume":"55","author":[{"given":"Ole Birger","family":"Pedersen","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology N\u00e6stved Hospital N\u00e6stved Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Skytthe","family":"Axel","sequence":"additional","affiliation":[{"name":"Danish Twin Registry University of Southern Denmark Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Rostgaard","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research Statens Serum Institut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Erikstrup","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustaf","family":"Edgren","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet Solna Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaspar Ren\u00e9","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aalborg Hospital Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Ullum","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten Ohm","family":"Kyvik","sequence":"additional","affiliation":[{"name":"Institute of Regional Health Research University of Southern Denmark and Odense Patient Data Explorative Network (OPEN), Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Hjalgrim","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research Statens Serum 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