{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:03:00Z","timestamp":1785801780247,"version":"3.56.0"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T00:00:00Z","timestamp":1428537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Invasive <jats:italic>Fusarium<\/jats:italic> infection is relatively refractory to available antifungal agents. Invasive fusariosis (IF) occurs almost exclusively in the setting of profound neutropenia and\/or systemic corticosteroid use. Treatment guidelines for IF are not well established, including the role of granulocyte transfusions (GTs) to counter neutropenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>We conducted a systematic review, identifying IF cases where GTs were used as adjunctive therapy to antifungal agents and also report a single\u2010center case series detailing our experience (1996\u20102012) of all IF cases treated with antifungal agents and GTs. In the systematic review cases, GTs were predominantly collected from nonstimulated donors whereas, in the case series, they were universally derived from dexamethasone\u2010 and granulocyte\u2013colony\u2010stimulating factor\u2013stimulated donors.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Twenty\u2010three patients met inclusion criteria for the systematic review and 11 for the case series. Response rates after GTs were 30 and 91% in the review and case series, respectively. Survival to hospital discharge remained low at 30 and 45%, respectively. Ten patients in the systematic review and three in the case series failed to achieve hematopoietic recovery and none of these survived. In the case series, donor\u2010stimulated GTs generated mean \u201csame\u2010day\u201d neutrophil increments of 3.35 \u00d7 10<jats:sup>9<\/jats:sup>\u2009\u00b1\u20091.24 \u00d7 10<jats:sup>9<\/jats:sup>\/L and mean overall posttransfusion neutrophil increments of 2.46 \u00d7 10<jats:sup>9<\/jats:sup>\u2009\u00b1\u20090.85 \u00d7 10<jats:sup>9<\/jats:sup>\/L. Progressive decrements in neutrophil response to GTs in two cases were attributed to GT\u2010related HLA alloimmunization.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>In patients with IF, donor\u2010stimulated GTs may contribute to high response rates by effectively bridging periods of neutropenia or marrow suppression. However, their utility in the absence of neutrophil recovery remains questionable.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13099","type":"journal-article","created":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T05:53:02Z","timestamp":1428558782000},"page":"2076-2085","source":"Crossref","is-referenced-by-count":52,"title":["Role of granulocyte transfusions in invasive fusariosis: systematic review and single\u2010center experience"],"prefix":"10.1111","volume":"55","author":[{"given":"Sameer S.","family":"Kadri","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine NIH Clinical Center National Institutes of Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth E.","family":"Remy","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine NIH Clinical Center National Institutes of Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R.","family":"Strich","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine MedStar\u2010Georgetown University Hospital Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Gea\u2010Banacloche","sequence":"additional","affiliation":[{"name":"National Cancer Institute Experimental Transplantation and Immunology Branch National Institutes of Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan F.","family":"Leitman","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine NIH Clinical Center National Institutes of Health Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.3.999"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/342328"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11510"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00014-07"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4161\/viru.2.2.15015"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/510592"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12409"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-013-1943-6"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/109.1.45"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/429331"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00286-10"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/503425"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-824900"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885066613498045"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/14653249.2010.529889"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2010.01035.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"crossref","first-page":"3605","DOI":"10.1182\/blood.V95.11.3605","article-title":"Effect of leukocyte compatibility on neutrophil increment after transfusion of granulocyte colony\u2010stimulating factor\u2010mobilized prophylactic granulocyte transfusions and on clinical outcomes after stem cell transplantation","volume":"95","author":"Adkins DR","year":"2000","journal-title":"Blood"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.2920100406"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.11.3302"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.010231"},{"key":"e_1_2_8_22_1","unstructured":"New England Research Institutes. Safety and effectiveness of granulocyte transfusions in resolving infection in people with neutropenia (the RING study). NLM identifier NCT00627393. Bethesda (MD): US National Library of Medicine; 2008 [cited 2015 Mar 18]. 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