{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T16:31:50Z","timestamp":1768494710331,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T00:00:00Z","timestamp":1428537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["(No. 81270642)"],"award-info":[{"award-number":["(No. 81270642)"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The efficacy and safety of sirolimus (SIR)\u2010based graft\u2010versus\u2010host disease (GVHD) prophylaxis in patients who were subjected to allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT) remain to be clarified; this meta\u2010analysis was conducted to evaluate these factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>Data from original research were obtained from PubMed, Embase, and Cochrane central register of controlled trials databases. Randomized controlled trials (RCTs) evaluating the efficacy of SIR\u2010based prophylaxis in allo\u2010HSCT were included. The risk ratio (RR), with a 95% confidence interval (CI), was used to pool data. The random effects model was used, irrespective of the presence or absence of heterogeneity.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Five RCTs were included in the meta\u2010analysis. SIR was observed to significantly decrease the incidence of Grade II to IV acute GVHD (aGVHD; RR, 0.65; 95% CI, 0.47\u20100.89). However, the incidence of Grade III to IV aGVHD and chronic GVHD was not decreased (RR, 0.91; 95% CI, 0.59\u20101.40; RR, 1.04; 95% CI, 0.88\u20101.23, respectively). An analysis of the toxic effects of SIR revealed that SIR effected a significant increase in the incidence of sinusoidal obstructive syndrome (RR, 2.24; 95% CI, 1.26\u20104.01), while that of thrombotic microangiopathy was not significantly increased (RR, 2.48; 95% CI, 0.87\u20107.06). Moreover, SIR did not improve event\u2010free survival and overall survival (RR, 0.97; 95% CI, 0.85\u20101.10; and RR, 0.92; 95% CI, 0.82\u20101.02, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>This meta\u2010analysis indicated that the SIR\u2010based regimen is an effective and safe alternative prophylaxis strategy for GVHD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13110","type":"journal-article","created":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T05:53:32Z","timestamp":1428558812000},"page":"2134-2141","source":"Crossref","is-referenced-by-count":14,"title":["The efficacy and safety of sirolimus\u2010based graft\u2010versus\u2010host disease prophylaxis in patients undergoing allogeneic hematopoietic stem cell transplantation: a meta\u2010analysis of randomized controlled trials"],"prefix":"10.1111","volume":"55","author":[{"given":"Li","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematology Chinese People's Liberation Army (PLA) General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenyang","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Hematology Chinese People's Liberation Army (PLA) General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiren","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Laoshan Branch of No. 401 Hospital of Chinese PLA Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology Chinese People's Liberation Army (PLA) General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shasha","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Hematology Chinese People's Liberation Army (PLA) General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Hematology Chinese People's Liberation Army (PLA) General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Hematology Chinese People's Liberation Army (PLA) General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaping","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Hematology Chinese People's Liberation Army (PLA) General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoxia","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Laoshan Branch of No. 401 Hospital of Chinese PLA Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology Chinese People's Liberation Army (PLA) General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daihong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology Chinese People's Liberation Army (PLA) General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quanshun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology Chinese People's Liberation Army (PLA) General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunji","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Hematology Chinese People's Liberation Army (PLA) General Hospital Beijing 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