{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:27:46Z","timestamp":1740126466648,"version":"3.37.3"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T00:00:00Z","timestamp":1432166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81102248","81101682"],"award-info":[{"award-number":["81102248","81101682"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003785","name":"Guangdong Provincial Medical Research Foundation","doi-asserted-by":"crossref","award":["B2010274"],"award-info":[{"award-number":["B2010274"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The operation of cord blood banks (CBBs) requires immense labor, material, and financial resources. Thus, increasing the ratio of high\u2010quality cord blood units (HQCBUs) in storage that are qualified for clinical use is critical for the efficient use of limited resources. Understanding the factors that contribute to HQCBUs, including maternal, fetal, and processing conditions, may improve the number of HQCBUs in storage.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>The maternal, fetal, and processing conditions of 4613 CBUs at the Guangzhou Cord Blood Bank were analyzed retrospectively to determine their effect on HQCBUs. All CBUs were obtained following strict standard operation procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Several factors may contribute to HQCBUs: fetal age older than 37 gestational weeks, female fetus, large cord blood (CB) volume (&gt;80 mL), high birthweight (&gt;3500 g), vaginal delivery, and a shorter amount of time between CB collection and processing (12 hr). We report for the first time that \u03b1\u2010thalassemia carriers exhibit a postprocessing total nucleated cell count (p\u2010TNCC) increase to at least 1.25 \u00d7 10<jats:sup>9<\/jats:sup> and an increase of the CD34+ cell count to at least 6.01 \u00d7 10<jats:sup>6<\/jats:sup>. Meconium\u2010stained amniotic fluid and mothers younger than 25 years of age exhibited increased p\u2010TNCC to at least 1.25 \u00d7 10<jats:sup>9<\/jats:sup>, and colony\u2010forming units increased to at least 23.24 \u00d7 10<jats:sup>5<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>We identified several factors that affect HQCBUs. These results may be used as a reference for updating CB collection strategies, with priority given to collecting CBUs from female fetuses older than 37 gestational weeks, at high birthweight, and born by vaginal delivery from mothers younger than 25 years of age, especially newborns with one parent carrying the trait or with meconium\u2010stained amniotic fluid. The collected CBUs should be sent to the laboratory as soon as possible for priority processing, which will help to increase the number and ratio of HQCBUs and the effective use of CBB resources.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13126","type":"journal-article","created":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T12:09:17Z","timestamp":1432210157000},"page":"2158-2167","source":"Crossref","is-referenced-by-count":12,"title":["Influence of maternal, infant, and collection characteristics on high\u2010quality cord blood units in Guangzhou Cord Blood Bank"],"prefix":"10.1111","volume":"55","author":[{"given":"Shaoqing","family":"Wu","sequence":"first","affiliation":[{"name":"Guangzhou Cord Blood Bank Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guie","family":"Xie","sequence":"additional","affiliation":[{"name":"Guangzhou Cord Blood Bank Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieying","family":"Wu","sequence":"additional","affiliation":[{"name":"Guangzhou Cord Blood Bank Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingsong","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangzhou Cord Blood Bank Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Lu","sequence":"additional","affiliation":[{"name":"Guangzhou Cord Blood Bank Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou Guangdong 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