{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:00:51Z","timestamp":1791320451371,"version":"4.3.1"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,5,18]],"date-time":"2015-05-18T00:00:00Z","timestamp":1431907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Hyperhemolysis in sickle cell disease is a rare and potentially life\u2010threatening complication of transfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>In this article we report a case of delayed hemolytic transfusion reaction with resultant hyperhemolysis triggered by an anti\u2010IH autoantibody with alloantibody behavior.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The anti\u2010IH was reactive at room temperature as well as 37\u00b0C, but only weakly reactive with autologous red blood cells. Initial cold agglutinin titer was 512. The profound, life\u2010threatening, intravascular hemolysis was rapidly and dramatically reduced with the Complement 5 (C5) inhibitory antibody, eculizumab. The auto\/allo cold agglutinin was subsequently suppressed with rituximab treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Eculizumab, a potent C5 inhibitory antibody, can be a rapid and effective therapy for hyperhemolytic transfusion reactions when given in a sufficient dose to fully block the activation of complement C5.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13144","type":"journal-article","created":{"date-parts":[[2015,5,18]],"date-time":"2015-05-18T10:36:21Z","timestamp":1431945381000},"page":"2398-2403","source":"Crossref","is-referenced-by-count":51,"title":["Life\u2010threatening delayed hyperhemolytic transfusion reaction in a patient with sickle cell disease: effective treatment with eculizumab followed by rituximab"],"prefix":"10.1111","volume":"55","author":[{"given":"Mark","family":"Boonyasampant","sequence":"first","affiliation":[{"name":"Department of Pathology Los Angeles County\u2010University of Southern California Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilene C.","family":"Weitz","sequence":"additional","affiliation":[{"name":"Jane Anne Nohl Division of Hematology Department of Medicine Keck School of Medicine Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Kay","sequence":"additional","affiliation":[{"name":"Department of Pathology Los Angeles County\u2010University of Southern California Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaiyaporn","family":"Boonchalermvichian","sequence":"additional","affiliation":[{"name":"Jane Anne Nohl Division of Hematology Department of Medicine Keck School of Medicine Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard A.","family":"Liebman","sequence":"additional","affiliation":[{"name":"Jane Anne Nohl Division of Hematology Department of Medicine Keck School of Medicine Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira A.","family":"Shulman","sequence":"additional","affiliation":[{"name":"Department of Pathology Los Angeles County\u2010University of Southern California Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1997.37497265334.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1997.37497265337.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1997.37497265338.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e3181c70e14"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01693.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02199.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1182\/blood.V83.3.842.842","article-title":"Defective regulation of complement by the sickle erythrocyte: evidence for a defect in control of the membrane attack complex 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