{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:33:28Z","timestamp":1789205608890,"version":"build-2803163510"},"reference-count":58,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,5,30]],"date-time":"2015-05-30T00:00:00Z","timestamp":1432944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"UK Blood Services","award":["Contract Reference NBS1024\/G\/AP"],"award-info":[{"award-number":["Contract Reference NBS1024\/G\/AP"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Variant Creutzfeldt\u2010Jakob disease (vCJD) is a transmissible spongiform encephalopathy affecting humans, acquired initially through infection with bovine spongiform encephalopathy (BSE). A small number of vCJD cases have been acquired through the transfusion of blood from asymptomatic donors who subsequently developed vCJD. Filter devices that selectively bind the infectious agent associated with prion disease have been developed for removal of infection from blood. This study independently assessed one such filter, the P\u2010CAPT filter, for efficacy in removing infectivity associated with the BSE agent in sheep blood. The sheep BSE model has previously been used to evaluate the distribution of infectivity in clinically relevant blood components. This is the first study to assess the ability of the P\u2010CAPT filter to remove endogenous infectivity associated with blood components prepared from a large animal model.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>Paired units of leukoreduced red blood cells (LR\u2010RBCs) were prepared from donors at the clinical stage of infection and confirmed as having BSE. One cohort of recipients was transfused with LR\u2010RBCs alone, whereas a parallel cohort received LR and P\u2010CAPT\u2013filtered RBCs (LR\u2010RBCs\u2010P\u2010CAPT).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Of 14 recipients, two have been confirmed as having BSE. These sheep had received LR\u2010RBCs and LR\u2010RBCs\u2010P\u2010CAPT from the same donor.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The results indicate that, after leukoreduction and P\u2010CAPT filtration, there can still be sufficient residual infectivity in sheep RBCs to transmit infection when transfused into a susceptible recipient.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13145","type":"journal-article","created":{"date-parts":[[2015,5,30]],"date-time":"2015-05-30T06:23:22Z","timestamp":1432967002000},"page":"2123-2133","source":"Crossref","is-referenced-by-count":7,"title":["A prion reduction filter does not completely remove endogenous prion infectivity from sheep blood"],"prefix":"10.1111","volume":"55","author":[{"given":"Sandra","family":"McCutcheon","sequence":"first","affiliation":[{"name":"Neurobiology Division The Roslin Institute, University of Edinburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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