{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T11:23:02Z","timestamp":1771327382839,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,6,22]],"date-time":"2015-06-22T00:00:00Z","timestamp":1434931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Bejing Municipal Science & Technology Commission","award":["Z121107002612035"],"award-info":[{"award-number":["Z121107002612035"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>We reported febrile reaction after the infusion of haploidentical peripheral blood stem cells (PBSCs). The aim of this study was to better characterize this new clinical entity named by infusion\u2010related febrile reaction (IRFR).<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>A retrospective analysis of 490 patients received allogeneic stem cell transplantation (SCT) between October 2009 and December 2011 at our institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The distribution of transplant type was 173 patients in HLA\u2010identical siblings, 30 in unrelated, and 287 in haploidentical. IRFR was defined as unexplained fever of more than 38\u00b0C within 24 hours after the infusion of allogeneic PBSCs. We did not observe any IRFRs in patients undergoing HLA\u2010identical sibling and unrelated transfusions. After excluding patients with a known source of infection, we classified haploidentical patients into IRFR and non\u2010IRFR groups. Eighty\u2010eight patients (30.7%) of 287 cases after the infusion of haploidentical PBSCs were diagnosed as IRFRs, chills in 3.5% (10\/88), diarrhea in 21.6% (19\/88), an erythematous skin rash in 0.3% (1\/88), hypoxemia in 1.0% (3\/88), and no other accompanying symptoms in 62.5% (55\/88). Significantly higher elevation of C\u2010reactive protein and complement C3 was seen in the IRFR group compared with the non\u2010IRFR group. Multivariate analysis showed higher CD34+ dose was a significant predictor for IRFR (p<jats:italic>=<\/jats:italic>0.023; hazard ratio\u2009=\u20091.848; 95% confidence interval, 1.087\u20103.142).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>As a clinical feature belonging to haploidentical SCT, IRFR was associated with the higher numbers of CD34+ from PBSCs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13167","type":"journal-article","created":{"date-parts":[[2015,6,22]],"date-time":"2015-06-22T10:51:27Z","timestamp":1434970287000},"page":"2023-2031","source":"Crossref","is-referenced-by-count":18,"title":["Febrile reaction associated with the infusion of haploidentical peripheral blood stem cells: incidence, clinical features, and risk factors"],"prefix":"10.1111","volume":"55","author":[{"given":"Yao","family":"Chen","sequence":"first","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology Beijing People's 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