{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T05:48:22Z","timestamp":1695620902954},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,6,22]],"date-time":"2015-06-22T00:00:00Z","timestamp":1434931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIGMS Exploratory","award":["1P20GM104317-01"],"award-info":[{"award-number":["1P20GM104317-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Drug\u2010induced immune thrombocytopenia (DITP) is a rare clinical disorder characterized by accelerated platelet (PLT) clearance in the presence of drug\u2010dependent antibodies. Distinguishing DITP from other immune\u2010mediated disorders such as posttransfusion purpura (PTP) and autoimmune thrombocytopenia can represent a clinical challenge.<\/jats:p><\/jats:sec><jats:sec><jats:title>CASE REPORT<\/jats:title><jats:p>A 68\u2010year\u2010old male with no prior transfusion history presented to the emergency department (ED) with dyspnea, epistaxis, and severe thrombocytopenia (&lt;10 \u00d7 10<jats:sup>9<\/jats:sup>\/L) 12 days after discharge from a hospital admission for a coronary artery bypass graft. Evaluation of the degree of thrombocytopenia and the temporal association between the peri\u2010 and postoperative receipt of multiple transfusions and the acute decrease in PLT count indicated PTP as a possible cause of the severe thrombocytopenia. Treatment with 1 g\/kg intravenous immunoglobulin (IVIG) was initiated and followed by a rapid 48\u2010hour increase in the PLT count. PLT antibodies lacking serologic specificity were subsequently identified in a sample collected upon presentation. Two weeks later he again presented to the ED with epistaxis and severe thrombocytopenia (&lt;10 \u00d7 10<jats:sup>9<\/jats:sup>\/L). Clinical history now revealed that the patient had been treated with trimethoprim\u2010sulfamethoxazole by his primary care physician after his first hospitalization for a \u201ccellulitic\u2010appearing\u201d leg and again before his final presentation for surgical site erythema and edema. IVIG was administered again with a rapid return of PLT count to baseline. Sulfamethoxazole\u2010dependent PLT antibodies were subsequently identified in the original patient sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>This case report documents a case of IVIG\u2010responsive DITP initially misdiagnosed as PTP, highlighting the clinical overlap of these immunologic\u2010mediated phenomena.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13197","type":"journal-article","created":{"date-parts":[[2015,6,22]],"date-time":"2015-06-22T11:13:18Z","timestamp":1434971598000},"page":"2738-2741","source":"Crossref","is-referenced-by-count":1,"title":["Sulfamethoxazole\u2010induced thrombocytopenia masquerading as posttransfusion purpura: a case report"],"prefix":"10.1111","volume":"55","author":[{"given":"Christian P.","family":"Nixon","sequence":"first","affiliation":[{"name":"Center for International Health Research Rhode Island Hospital and Alpert Medical School of Brown University Providence Rhode Island"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracey A.","family":"Cheves","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine Rhode Island Hospital and the Miriam Hospitals, Alpert Medical School of Brown University Providence Rhode Island"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph D.","family":"Sweeney","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine Rhode Island Hospital and the Miriam Hospitals, Alpert Medical School of Brown University Providence Rhode Island"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,22]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1325","volume-title":"Wintrobe's clinical hematology","author":"Bithell TC.","year":"1993"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.1985.tb00002.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2012.02.007"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(00)00311-X"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012369367-9\/50811-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.20.2518"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH04-12-0825"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00320364"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00319544"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/106002809002400706"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra066469"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0268-960X(89)90002-7"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1986.tb02198.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1996.486822000.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002280050272"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1981.tb09853.x"},{"key":"e_1_2_6_18_1","first-page":"535","article-title":"Thrombocytopenia. 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