{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T07:51:30Z","timestamp":1764402690486},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T00:00:00Z","timestamp":1439337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Metabolic alkalosis occurs as a direct result of plasma exchange (PE) because of metabolism of citrate. However, we observed a decrease of serum pH and bicarbonate after PE when albumin was used as replacement fluid.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>The acid\u2013base balance in 2730 PEs using different replacement fluids (albumin, fresh\u2010frozen plasma [FFP], or both) was measured, and absolute changes (\u0394) in acid\u2013base balance were compared. The frequency of adverse effects (AEs) before and after using prophylactic administration of sodium bicarbonate was compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A decrease of serum pH and bicarbonate was observed after PEs when albumin was used as replacement fluid (\u0394 pH\u2009=\u2009\u22120.06\u2009\u00b1\u20090.04; \u0394 bicarbonate\u2009=\u2009\u22124.03\u2009\u00b1\u20092.29 mmol\/L; \u0394 base excess\u2009=\u2009\u22122.54\u2009\u00b1\u20093.82 mmol\/L). An increase of serum pH and bicarbonate was observed after PEs when FFP was used as replacement fluid (\u0394 pH\u2009=\u2009+0.04\u2009\u00b1\u20090.05; \u0394 bicarbonate\u2009=\u2009+3.6\u2009\u00b1\u20093.68 mmol\/L; \u0394 base excess\u2009=\u2009+1.62\u2009\u00b1\u20094.51 mmol\/L). The prophylactic administration of sodium bicarbonate corrected partially the decrease of serum pH and bicarbonate after finishing PEs when albumin was used as replacement fluid (\u0394 pH\u2009=\u2009\u22120.04\u2009\u00b1\u20090.04; \u0394 bicarbonate\u2009=\u2009\u22123.1\u2009\u00b1\u20092.47 mmol\/L; \u0394 base excess\u2009=\u2009\u22123.35\u2009\u00b1\u20093.06 mmol\/L). The frequency of AEs after using prophylactic administration of sodium bicarbonate was lower in comparison with the frequency of AEs before using prophylactic administration of sodium bicarbonate (2.0% vs. 4.8%; p\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>A decrease of serum pH and bicarbonate appeared in patients after PEs when albumin was used as replacement fluid; it was corrected partially with prophylactic administration of sodium bicarbonate, and it was associated with fewer AEs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13215","type":"journal-article","created":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T13:38:07Z","timestamp":1439386687000},"page":"2653-2658","source":"Crossref","is-referenced-by-count":16,"title":["Acid\u2013base balance disturbances in plasma exchange depend on the replacement fluid used"],"prefix":"10.1111","volume":"55","author":[{"given":"Joan","family":"Cid","sequence":"first","affiliation":[{"name":"Apheresis Unit Department of Hemotherapy and Hemostasis CDB, IDIBAPS, Hospital Cl\u00ednic, University de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"Carbass\u00e9","sequence":"additional","affiliation":[{"name":"Apheresis Unit Department of Hemotherapy and Hemostasis CDB, IDIBAPS, Hospital Cl\u00ednic, University de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montse","family":"Gamir","sequence":"additional","affiliation":[{"name":"Apheresis Unit Department of Hemotherapy and Hemostasis CDB, IDIBAPS, Hospital Cl\u00ednic, University de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Apheresis Unit Department of Hemotherapy and Hemostasis CDB, IDIBAPS, Hospital Cl\u00ednic, University de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Arellano\u2010Rodrigo","sequence":"additional","affiliation":[{"name":"Apheresis Unit Department of Hemotherapy and Hemostasis CDB, IDIBAPS, Hospital Cl\u00ednic, University de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Lozano","sequence":"additional","affiliation":[{"name":"Apheresis Unit Department of Hemotherapy and Hemostasis CDB, IDIBAPS, Hospital Cl\u00ednic, University de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,12]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"45","volume-title":"Apheresis: principles and practice","author":"Crookston 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