{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:17:39Z","timestamp":1791310659582,"version":"4.3.1"},"reference-count":56,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T00:00:00Z","timestamp":1439164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH"},{"name":"NHLBI and by DHHS OASH"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>On March 25 and 26, 2015, the National Heart, Lung, and Blood Institute sponsored a meeting on the State of the Science in Transfusion Medicine on the National Institutes of Health (NIH) campus in Bethesda, Maryland, which was attended by a diverse group of 330 registrants. The meeting's goal was to identify important research questions that could be answered in the next 5 to 10 years and which would have the potential to transform the clinical practice of transfusion medicine. These questions could be addressed by basic, translational, and\/or clinical research studies and were focused on four areas: the three \u201cclassical\u201d transfusion products (i.e., red blood cells, platelets, and plasma) and blood donor issues. Before the meeting, four working groups, one for each area, prepared five major questions for discussion along with a list of five to 10 additional questions for consideration. At the meeting itself, all of these questions, and others, were discussed in keynote lectures, small\u2010group breakout sessions, and large\u2010group sessions with open discourse involving all meeting attendees. In addition to the final lists of questions, provided herein, the meeting attendees identified multiple overarching, cross\u2010cutting themes that addressed issues common to all four areas; the latter are also provided. It is anticipated that addressing these scientific priorities, with careful attention to the overarching themes, will inform funding priorities developed by the NIH and provide a solid research platform for transforming the future practice of transfusion medicine.<\/jats:p>","DOI":"10.1111\/trf.13250","type":"journal-article","created":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T00:39:00Z","timestamp":1439253540000},"page":"2282-2290","source":"Crossref","is-referenced-by-count":68,"title":["2015 proceedings of the National Heart, Lung, and Blood Institute's State of the Science in Transfusion Medicine symposium"],"prefix":"10.1111","volume":"55","author":[{"given":"Steven L.","family":"Spitalnik","sequence":"first","affiliation":[{"name":"Department of Pathology &amp; Cell Biology Columbia University Medical Center\u2013New York Presbyterian Hospital New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrell","family":"Triulzi","sequence":"additional","affiliation":[{"name":"Institute for Transfusion Medicine and Department of Pathology University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana V.","family":"Devine","sequence":"additional","affiliation":[{"name":"Canadian Blood Services and the Centre for Blood Research University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter H.","family":"Dzik","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne F.","family":"Eder","sequence":"additional","affiliation":[{"name":"National Headquarters, American Red Cross Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Gernsheimer","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Washington Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra D.","family":"Josephson","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine Emory University School of Medicine Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryl J.","family":"Kor","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Mayo Clinic College of Medicine Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi L. C.","family":"Luban","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine, Center for Cancer and Blood Disease Children's National Health System, and the Department of Pediatrics, George Washington University School of Medicine Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nareg H.","family":"Roubinian","sequence":"additional","affiliation":[{"name":"Blood Systems Research Institute, and the Department of Laboratory Medicine, University of California San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Traci","family":"Mondoro","sequence":"additional","affiliation":[{"name":"Division of Blood Diseases and Resources National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH) Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisbeth A.","family":"Welniak","sequence":"additional","affiliation":[{"name":"Division of Blood Diseases and Resources National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH) Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimian","family":"Zou","sequence":"additional","affiliation":[{"name":"Division of Blood Diseases and Resources National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH) Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Glynn","sequence":"additional","affiliation":[{"name":"Division of Blood Diseases and Resources National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH) Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the State of the Science in Transfusion Medicine Working Groups","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-146415"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-327361"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V76.7.1431.1431"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00007.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12585"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12867"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2014.12.016"},{"key":"e_1_2_10_9_1","first-page":"293","article-title":"Deriving blood stem cells from pluripotent stem cells for research and therapy","volume":"27","author":"Daley GQ.","year":"2014","journal-title":"Clin Haematol"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/biot.201200368"},{"key":"e_1_2_10_11_1","first-page":"199","article-title":"Cultured blood versus donated blood: long\u2010run perspectives of the economy of blood","volume":"25","author":"Mercier Ythier J.","year":"2015","journal-title":"Biomed Mater Eng"},{"key":"e_1_2_10_12_1","first-page":"CD002042","article-title":"Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion","volume":"4","author":"Carson JL","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2013.03.001"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12565"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.2726"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2001.41080977.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3182707ae5"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01485.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2012.04.005"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60673-X"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60650-9"},{"key":"e_1_2_10_22_1","first-page":"173","article-title":"Physiologic transfusion triggers","volume":"21","author":"Vallet B","year":"2007","journal-title":"Clin Anaesthesiol"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc2846"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddmec.2011.06.001"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/1076029614559771"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12943"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2005.04.003"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2011.09.021"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2009.07.003"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-501247"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e32833e7561"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn503732m"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-09-455428"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1990.tb04356.x"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2001.41060790.x"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2009.01167.x"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2010.175"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12750"},{"key":"e_1_2_10_39_1","volume-title":"Transfusion therapy: clinical principals and practice","author":"Callum J","year":"2010"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-13-137"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318264c644"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1208626"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2012.08.047"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.25011\/cim.v30i2.985"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3181801cd9"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12039"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e31820e83be"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.121986"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.12"},{"key":"e_1_2_10_50_1","unstructured":"Food and Drug Administration. Draft Guidance for Industry: revised recommendations for reducing the risk of human immunodeficiency virus transmission by blood and blood products. Silver Spring (MD): US Department of Health and Human Services Food and Drug Administration Center for Biologics Evaluation and Research; May 2015."},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2011.01526.x"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.070979"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03401.x"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2010.01439.x"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12861"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.19.2279"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2011.01494.x"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.13250","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.13250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T09:37:06Z","timestamp":1695548226000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.13250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,10]]},"references-count":56,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/trf.13250"],"URL":"https:\/\/doi.org\/10.1111\/trf.13250","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,10]]}}}