{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T12:44:58Z","timestamp":1772887498464,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T00:00:00Z","timestamp":1439251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Cellular engraftment after allogeneic hematopoietic progenitor cell transplantation (HPCT) can be affected by pre\u2010HPCT antibodies against donor human leukocyte antigen (HLA; donor\u2010specific antibodies [DSAs]), which are commonly acquired by either pregnancy or transfusion. Issues regarding high assay sensitivity and variable interpretation limit routine screening for DSAs. Platelet (PLT) transfusion refractoriness (PTR) is relatively common in patients with hematologic malignancies, and anti\u2010HLA alloantibodies can be identified in up to 20% of cases. For patients with PTR undergoing subsequent allogeneic HPCT, however, the effect if any on subsequent PLT nonengraftment is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>We conducted a retrospective study of 480 adults who underwent T\u2010replete HPCT for hematologic malignancy and compared the posttransplantation clinical outcomes between patients who were PTR before HPCT and those who were not.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Multivariate analysis demonstrated that PTR was not directly associated with PLT nonengraftment or graft failure, but did predict for early intensive care unit admission, which was the only variable associated with these outcomes (p\u2009&lt;\u20090.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Our findings suggest that PTR before HPCT identifies patients at higher risk of early clinical rather than immunologic complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13263","type":"journal-article","created":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T05:09:56Z","timestamp":1439356196000},"page":"164-169","source":"Crossref","is-referenced-by-count":8,"title":["Pretransplant platelet transfusion refractoriness is not associated with platelet nonengraftment in T\u2010replete hematopoietic progenitor cell transplantation for hematologic malignancies"],"prefix":"10.1111","volume":"56","author":[{"given":"Ashleigh","family":"Scott","sequence":"first","affiliation":[{"name":"Department of Haematology and Bone Marrow Transplantation Royal Brisbane and Women's Hospital Herston"},{"name":"Australian Red Cross Blood Service Kelvin Grove"},{"name":"Pathology Queensland Herston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoma","family":"Baidya","sequence":"additional","affiliation":[{"name":"Australian Red Cross Blood Service Kelvin Grove"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Butler","sequence":"additional","affiliation":[{"name":"Department of Haematology and Bone Marrow Transplantation Royal Brisbane and Women's Hospital Herston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirk","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Haematology and Bone Marrow Transplantation Royal Brisbane and Women's Hospital Herston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alycia","family":"Thornton","sequence":"additional","affiliation":[{"name":"Pathology Queensland Herston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glen A.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Department of Haematology and Bone Marrow Transplantation Royal Brisbane and Women's Hospital Herston"},{"name":"The University of Queensland St Lucia Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.13.4096"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2007.10.025"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2011.131"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-09-244525"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181b9d710"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-362111"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12040"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-05-355263"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.077685"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2011.249"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07189.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199712253372601"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02206.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-03-0940"},{"key":"e_1_2_9_16_1","first-page":"825","article-title":"1994 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