{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:58:47Z","timestamp":1790355527347,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T00:00:00Z","timestamp":1444176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>ABO incompatibility is not a contraindication to hematopoietic cell transplantation (HCT), but it has been associated with additional risks including delayed engraftment, pure red cell aplasia (PRCA), and higher transfusion needs. Data on these events and on patient survival after reduced\u2010intensity conditioning (RIC) HCT are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>A total of 127 consecutive patients, 86 with acute myeloid leukemia and 41 with myelodysplastic syndromes, who underwent HLA\u2010matched peripheral blood RIC allogenic HCT between 2005 and 2014 were retrospectively analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Eighty ABO\u2010compatible, 26 major\/bidirectional, and 21 minor\u2010ABO\u2010mismatch HCT were identified. Compared to the ABO\u2010compatible group, major\/bidirectional mismatches had increased red blood cell (RBC) transfusion requirement during the first 100 days (p\u2009=\u20090.009), delayed RBC and PLT engraftment (p\u2009=\u20090.0011 and p\u2009=\u20090.005, respectively), and higher incidence of grade II to IV acute graft\u2010versus\u2010host disease (aGVHD; p\u2009=\u20090.037). In multivariable analysis, major\/bidirectional mismatches had significantly higher non\u2010relapse mortality (NRM) and inferior disease\u2010free survival (DFS) and overall survival (OS) compared with ABO\u2010compatible patients (p\u2009=\u20090.01, p\u2009=\u20090.04, and p\u2009=\u20090.035, respectively). Minor ABO mismatch had no impact on survival (p <jats:italic>=<\/jats:italic> 0.99). Four (15%) of 26 major\/bidirectional mismatches developed PRCA. There was a significant association between fludarabine plus busulfan conditioning and PRCA (p\u2009=\u20090.0046).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Major\/bidirectional ABO mismatch is associated with higher NRM and shortened DFS and OS in the setting of RIC HCT. Increased transfusion need, delayed RBC and platelet engraftment, PRCA, and increased severity of aGVHD are additional complications contributing to the morbidity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13353","type":"journal-article","created":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T04:42:50Z","timestamp":1444279370000},"page":"518-527","source":"Crossref","is-referenced-by-count":13,"title":["ABO blood group incompatibility as an adverse risk factor for outcomes in patients with myelodysplastic syndromes and acute myeloid leukemia undergoing HLA\u2010matched peripheral blood hematopoietic cell transplantation after reduced\u2010intensity conditioning"],"prefix":"10.1111","volume":"56","author":[{"given":"Mehrdad","family":"Hefazi","sequence":"first","affiliation":[{"name":"Department of Medicine Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Litzow","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Hogan","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Gastineau","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eapen","family":"Jacob","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moussab","family":"Damlaj","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester 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