{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:47:35Z","timestamp":1775065655657,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T00:00:00Z","timestamp":1444176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Plasma volume reduction (PVR) may reduce the risk of hemolysis associated with transfusion of plateletpheresis blood products (PLTs) containing ABO\u2010incompatible plasma. But PVR may delay PLT issue. In collaboration with our blood donor center we evaluated an automated screen of PLT for high\u2010titer ABO antibody and to apply PVR to high\u2010titer PLTs.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>At the donor center, plasma from PLT donors was tested using an automated microplate system (PK7300, Beckman). PK settings were set for a detection cutoff equivalent to 1 in 256 using a manual tube method. The donors associated with high\u2010titer PLTs were characterized by sex and age. In the transfusion service, the number of PVR procedures was evaluated before and after implementation of the high\u2010titer screen.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>During validation, 157 of 1008 PLT units (15%) were positive by the automated method versus 121 (12%) by manual method. After implementation, 2112 of 15,240 PLT units were high\u2010titer, with higher frequency in donations from females versus males (18% vs. 12%, p\u2009&lt;\u20090.0001). The PLT PVR rate was reduced by 50%.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Implementation of an automated method to screen PLTs for high\u2010titer ABO antibody at the donor center improves the inventory management of PLTs containing ABO\u2010incompatible plasma at the hospital transfusion service.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13374","type":"journal-article","created":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T04:41:02Z","timestamp":1444279262000},"page":"2783-2789","source":"Crossref","is-referenced-by-count":12,"title":["How do I implement an automated screen for high\u2010titer ABO antibody as an inventory management tool for ABO plasma\u2013incompatible platelets?"],"prefix":"10.1111","volume":"55","author":[{"given":"Magali J.","family":"Fontaine","sequence":"first","affiliation":[{"name":"Department of Pathology University of Maryland Baltimore Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Webster","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University Stanford California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Gomez","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University Stanford California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tho D.","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University Stanford California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence T.","family":"Goodnough","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University Stanford California"},{"name":"Department of Medicine Stanford University Stanford California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan A.","family":"Galel","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University Stanford California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2009.10.013"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.5858\/2007-131-909-TOPCAP"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03596.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03476.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2006.00684.x"},{"key":"e_1_2_7_7_1","first-page":"116A","article-title":"Rapid detection of high titer anti\u2010a\/anti\u2010B in blood donors using an Olympus PK 7200 [abstract]","volume":"49","author":"Novaretti MC","year":"2009","journal-title":"Transfusion"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02759.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02208.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03574.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000296019.85986.af"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.5581\/1516-8484.20110073"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12597"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2010.01389.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12498"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.13374","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.13374","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.13374","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T15:11:11Z","timestamp":1696000271000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.13374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,7]]},"references-count":14,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/trf.13374"],"URL":"https:\/\/doi.org\/10.1111\/trf.13374","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,7]]}}}