{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:39:07Z","timestamp":1773297547141,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T00:00:00Z","timestamp":1444867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP 97911"],"award-info":[{"award-number":["MOP 97911"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Transfusing ABO\u2010compatible blood avoids most acute hemolytic reactions, but donor units that are ABO compatible are not necessarily ABO identical. Emerging data have raised concerns that ABO\u2010nonidentical blood products lead to adverse outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY DESIGN AND METHODS<\/jats:title>\n                    <jats:p>A large multihospital registry (Transfusion Registry for Utilization, Surveillance, and Tracking) was used to determine the association between exposure to ABO\u2010nonidentical blood and in\u2010hospital mortality. Cox regression analyses controlled for sex, age, hemoglobin, creatinine, and in\u2010hospital interventions and stratified by age of blood and admission year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Data from 18,843 non\u2013group O patients admitted between 2002 and 2011 and receiving at least 1\u00a0unit of blood were analyzed. Overall, group A patients had significantly increased risk of in\u2010hospital death upon receiving a nonidentical unit (RR\u00a0, 1.79; 95% CI, 1.20\u20102.67; p\u00a0=\u00a00.005). There was no evidence of increased risk for group B or AB patients. Similar results were seen when only patients with circulatory disorders were considered. When patients with an injury or poisoning diagnosis were excluded, the risk of in\u2010hospital death after receiving a non\u2010identical unit was significantly higher in group A patients and significantly lower in Group B patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Our study demonstrates an adverse effect of ABO\u2010nonidentical blood in a broad range of patients with group A blood, after adjustment for potential confounders. Further research in this area is required to study possible mechanisms. Increased mortality associated with exposure to nonidentical blood in these patients would have a substantial impact at the population level; it would challenge how blood suppliers manage inventory and recruit donors and how health care providers administer blood.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.13376","type":"journal-article","created":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T23:53:00Z","timestamp":1444953180000},"page":"550-557","source":"Crossref","is-referenced-by-count":21,"title":["Exposure to\n                    <scp>ABO<\/scp>\n                    \u2010nonidentical blood associated with increased in\u2010hospital mortality in patients with group\n                    <scp>A<\/scp>\n                    blood"],"prefix":"10.1111","volume":"56","author":[{"given":"Menaka","family":"Pai","sequence":"first","affiliation":[{"name":"Transfusion Research Program"},{"name":"Department of Medicine McMaster University Hamilton Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Statistics and Actuarial Science University of Waterloo Waterloo Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Barty","sequence":"additional","affiliation":[{"name":"Transfusion Research Program"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Eikelboom","sequence":"additional","affiliation":[{"name":"Department of Medicine McMaster University Hamilton Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ker\u2010Ai","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Statistics and Actuarial Science University of Waterloo Waterloo Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Heddle","sequence":"additional","affiliation":[{"name":"Transfusion Research Program"},{"name":"Department of Medicine McMaster University Hamilton Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2009.10.013"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/tmrv.2003.50003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2010.175"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e31818e8ff3"},{"key":"e_1_2_7_6_1","unstructured":"R Development Core Team. 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