{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T18:54:58Z","timestamp":1781117698023,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T00:00:00Z","timestamp":1448236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Many biologic functions depend on sufficient iron levels, and iron deficiency is especially common among blood donors. Genetic variants associated with iron levels have been identified, but the impact of genetic variation on iron levels among blood donors remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>The effect of six single\u2010nucleotide polymorphisms (SNPs) on ferritin levels in 14,126 blood donors were investigated in four genes: in Human Hemochromatosis Protein gene (<jats:italic>HFE;<\/jats:italic> rs1800562 and rs179945); in Transmembrane Protease gene, Serine 6 (<jats:italic>TMPRSS6<\/jats:italic>\u2010regulating hepcidin; rs855791); in BTB domain containing protein gene (<jats:italic>BTBD9<\/jats:italic>\u2014associated with restless legs syndrome; rs9357271); and in the Transferrin gene (<jats:italic>TF<\/jats:italic>; rs2280673 and rs1830084). Multiple linear and logistic regression analyses were used to evaluate the effect of each SNP on ferritin levels and the risk of iron deficiency (ferritin\u2009&lt;\u200915 ng\/mL).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In <jats:italic>HFE<\/jats:italic>, the G\u2010allele of rs1800562 was associated with lower iron stores in both sexes. This was also true for the C\u2010allele of rs179945, but in men only. Also, the T\u2010allele of <jats:italic>TMPRSS6<\/jats:italic> rs855791 was negatively associated with iron stores in men. Homozygocity for C in rs1799945 was associated with iron deficiency in women. Results for all other genetic variants were insignificant.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Genetic variants associated with hemochromatosis may protect donors against depleted iron stores. In addition, we showed that presence of the T\u2010allele at rs855791 in <jats:italic>TMPRSS6<\/jats:italic> was associated with lower iron stores in men.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13397","type":"journal-article","created":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T04:45:23Z","timestamp":1448340323000},"page":"622-627","source":"Crossref","is-referenced-by-count":24,"title":["Genetic factors influencing ferritin levels in 14,126 blood donors: results from the Danish Blood Donor Study"],"prefix":"10.1111","volume":"56","author":[{"given":"Erik","family":"S\u00f8rensen","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas S.","family":"Rigas","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise W.","family":"Th\u00f8rner","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristoffer S.","family":"Burgdorf","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole B.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Naestved Hospital Naestved Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikkel S.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Hjalgrim","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research Statens Serum Institut Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Erikstrup","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Ullum","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital Copenhagen 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