{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:24:54Z","timestamp":1789878294655,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T00:00:00Z","timestamp":1451347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Transplant\u2010associated thrombotic microangiopathy (TA\u2010TMA) after hematopoietic stem cell transplantation (HSCT) remains a severe complication associated with underlying endothelial damage. TMA has a high mortality rate with no definite treatments and effective treatments are needed.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>The study objective was to retrospectively analyze the outcome of patients receiving recombinant human soluble thrombomodulin (rTM), which has cytoprotective effects against calcineurin inhibitor\u2013induced endothelial cell damage, or other therapeutics for TA\u2010TMA from 254 consecutive HSCT recipients between 2009 to 2014 at a single institution. We hypothesized that patients receiving rTM as a first\u2010line treatment would receive a benefit.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Sixteen patients were diagnosed as TA\u2010TMA. Of these 16 patients, nine were treated with rTM (rTM group), and seven received treatment other than rTM (control group) as a first\u2010line therapy. Seven of the nine patients in the rTM group recovered from TA\u2010TMA without complications, but none in the control group recovered. The rTM group showed a significantly better overall survival after TA\u2010TMA onset than did the control group (median, 123.0 days vs. 45.5 days, respectively; p\u2009=\u20090.045). The cumulative incidence of acute graft\u2010versus\u2010host disease was the same in both groups (56% vs. 57%, respectively; p\u2009=\u20090.52) on Day 100 after TA\u2010TMA onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>This is the first report evaluating rTM administration for TA\u2010TMA compared with previous treatments. Our data suggests that rTM might offer a better clinical outcome in patients with TA\u2010TMA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13437","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T10:15:02Z","timestamp":1451384102000},"page":"886-892","source":"Crossref","is-referenced-by-count":31,"title":["Treatment of thrombotic microangiopathy after hematopoietic stem cell transplantation with recombinant human soluble thrombomodulin"],"prefix":"10.1111","volume":"56","author":[{"given":"Hideaki","family":"Fujiwara","sequence":"first","affiliation":[{"name":"Department of Hematology Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology and Respiratory Medicine, Okayama University Graduate School 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