{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T23:52:00Z","timestamp":1783727520538,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,2,18]],"date-time":"2016-02-18T00:00:00Z","timestamp":1455753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Extracorporeal photopheresis (ECP) culls pathogenic T lymphocytes, be these the clones of cutaneous T\u2010cell lymphoma, or mediators of chronic graft\u2010versus\u2010host disease (GVHD) after allogeneic bone marrow transplantation (BMT\u2010GVHD). Whether or not ECP may have an effect in the rarer instances of solid organ transplantation\u2013associated GVHD (SOT\u2010GVHD) is unclear. Mortality rates in SOT\u2010GVHD rival those of transfusion\u2010associated GVHD, with fatalities preceded by pancytopenia and peripheral blood chimerism (PBC) levels exceeding 20%. ECP has been described in two SOT\u2010GVHD cases to date, with one surviving.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>Clinicolaboratory features (including HLA relationships) in a case of multivisceral transplantation were reviewed from the time of surgery to the onset and progression of SOT\u2010GVHD. ECP, which was introduced as a less immunosuppressive and more selective intervention, was assessed for its effect on serial PBC (as measured by short\u2010tandem\u2010repeat analysis) and clinical outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Multivisceral SOT\u2010GVHD manifested with erythroderma, neutropenic sepsis, and PBC increasing from 6% on Posttransplant Day (PTD) 38 to 78% by PTD 60 (at a doubling time of 6 days despite corticosteroids). ECP was administered on PTDs 62 and 67 and was associated with the first evidence of PBC decay to 67% on PTD 69. Death nevertheless ensued on the last day of salvage antithymocyte globulin (PTDs 69\u201073) despite further PBC reduction to 41%.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Further study is needed to determine if the sooner or more frequent application of ECP might attenuate the high case fatality rates of SOT\u2010GVHD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13467","type":"journal-article","created":{"date-parts":[[2016,2,20]],"date-time":"2016-02-20T13:01:44Z","timestamp":1455973304000},"page":"962-969","source":"Crossref","is-referenced-by-count":14,"title":["Extracorporeal photopheresis in solid organ transplant\u2013associated acute graft\u2010versus\u2010host disease"],"prefix":"10.1111","volume":"56","author":[{"given":"Brett L.","family":"Houston","sequence":"first","affiliation":[{"name":"Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Tinckam","sequence":"additional","affiliation":[{"name":"Department of Medicine"},{"name":"Laboratory Medicine Program University Health Network and University of Toronto Toronto Ontario"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Kamel\u2010Reid","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Program University Health Network and University of Toronto Toronto Ontario"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chang","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Program University Health Network and University of Toronto Toronto Ontario"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin H.M.","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Medicine"},{"name":"Department of Medical Oncology and Hematology University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Tsien","sequence":"additional","affiliation":[{"name":"Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Seftel","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology, CancerCare Manitoba, and Section of Hematology\/Oncology, Department of Internal Medicine University of Manitoba Winnipeg Manitoba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaron","family":"Avitzur","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Hospital for Sick Children Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Grant","sequence":"additional","affiliation":[{"name":"Department of Surgery University Health Network and University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Cserti\u2010Gazdewich","sequence":"additional","affiliation":[{"name":"Department of Medicine"},{"name":"Department of Medical Oncology and Hematology University of Toronto"},{"name":"Laboratory Medicine Program University Health Network and University of Toronto Toronto Ontario"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2012.08.002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2004.00524.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200301150-00022"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2007.00625.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199709000-00002"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2009.06.229"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01110.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20982"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01835.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.12659\/AOT.883704"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2008.00754.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12862"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000103721.29729.FE"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-01-620872"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2014.04.006"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2005.04.002"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2006.10.003"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199409223311202"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199807150-00006"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000078895.24606.45"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2007.01.001"},{"key":"e_1_2_8_23_1","first-page":"CD005341","article-title":"Granulocyte transfusions for preventing infections in patients with neutropenia or neutrophil dysfunction","volume":"1","author":"Massey E","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/iji.12017"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12341"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2014.09.012"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703162"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70184-U"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ics.2005.08.045"},{"key":"e_1_2_8_30_1","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.5858\/2008-0679-RS.1","article-title":"Solid organ transplant\u2010associated acute graft\u2010versus\u2010host disease","volume":"134","author":"Zhang Y","year":"2010","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-012-2047-7"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12107"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804647"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005030293"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12807"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014080837"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21333"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2011.10.018"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-08-551994"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199507000-00009"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12200"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040620713490316"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701733"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-498279"},{"key":"e_1_2_8_45_1","first-page":"18","article-title":"In search of immunological tolerance through stem cell transplantation","volume":"15","author":"Bucciarelli A.","year":"2013","journal-title":"AABB News: The Magazine for Transfusion and Cellular Therapies Professionals"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i25.8215"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.13467","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.13467","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.13467","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T07:49:26Z","timestamp":1694850566000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.13467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,18]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1111\/trf.13467"],"URL":"https:\/\/doi.org\/10.1111\/trf.13467","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,18]]}}}