{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T06:15:46Z","timestamp":1695622546642},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,1,26]],"date-time":"2016-01-26T00:00:00Z","timestamp":1453766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Neonatal alloimmune thrombocytopenia (NAIT) has been reported only rarely in twins and not at all, to our knowledge, in triplets.<\/jats:p><\/jats:sec><jats:sec><jats:title>CASE REPORT<\/jats:title><jats:p>Nonidentical triplets were born with severe thrombocytopenia. Nadir platelet (PLT) counts were 17\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>, 12\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>, and 10\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L. NAIT was confirmed by an incompatibility for human PLT antigen (HPA)\u22121a and the presence of maternal anti\u2010HPA\u20101a. The maternal genotype was HPA\u20101bb and the paternal genotype was HPA\u20101aa; thus, all children were affected.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>PLT counts for each infant improved with the administration of random\u2010donor PLT transfusions. All three infants also received intravenous immunoglobulin. None had major bleeding. A small isolated subependymal hemorrhage was found incidentally in one infant; this remained stable on repeat imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>This is the first report of triplets with NAIT. Anti\u2010HPA\u20101a is sufficiently potent to affect three infants simultaneously. Random\u2010donor PLTs were effective in improving PLT counts in all three infants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13494","type":"journal-article","created":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T04:24:43Z","timestamp":1453868683000},"page":"1166-1170","source":"Crossref","is-referenced-by-count":0,"title":["Triplets with neonatal alloimmune thrombocytopenia due to antibodies against human platelet antigen 1a"],"prefix":"10.1111","volume":"56","author":[{"given":"Ziad","family":"Solh","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Hematology and Oncology, McMaster Children's Hospital, McMaster University, Hamilton, ON"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicky","family":"Breakey","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Hematology and Oncology, McMaster Children's Hospital, McMaster University, Hamilton, 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