{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:01:40Z","timestamp":1787317300780,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T00:00:00Z","timestamp":1462924800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Intramural research programs of the NHLBI, NIDDK and the Clinical Center, NIH"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Granulocyte\u2013colony\u2010stimulating factor (G\u2010CSF)\u2010stimulated hematopoietic progenitor cells (HPCs) collected by apheresis have become the predominant graft source for HPC transplantation in adults. Among healthy allogeneic donors, demographic characteristics (age, sex, body mass index [BMI]) and baseline hematologic counts affect HPC mobilization, leading to variability in CD34+ apheresis yields. Racial differences in HPC mobilization are less well characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY DESIGN AND METHODS<\/jats:title>\n                    <jats:p>We retrospectively analyzed data from 1096 consecutive G\u2010CSF\u2013stimulated leukapheresis procedures in healthy allogeneic African American (AA) or Caucasian donors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In a multivariate analysis, after adjusting for age, sex, BMI, baseline platelet and mononuclear cell counts, and daily G\u2010CSF dose, peak CD34+ cell mobilization was significantly higher among AAs (n\u2009=\u2009215) than Caucasians (n\u2009=\u2009881; 123\u2009\u00b1\u200987 \u00d7 10\n                      <jats:sup>6<\/jats:sup>\n                      cells\/L vs. 75\u2009\u00b1\u200947 \u00d7 10\n                      <jats:sup>6<\/jats:sup>\n                      cells\/L; p\u2009&lt;\u20090.0001). A ceiling effect was observed with increasing G\u2010CSF dose (10 \u00b5g\/kg\/day vs. 16 \u00b5g\/kg\/day) in AAs (123\u2009\u00b1\u200988 \u00d7 10\n                      <jats:sup>6<\/jats:sup>\n                      cells\/L vs. 123\u2009\u00b1\u200987 \u00d7 10\n                      <jats:sup>6<\/jats:sup>\n                      cells\/L) but not in Caucasians (74\u2009\u00b1\u200946 \u00d7 10\n                      <jats:sup>6<\/jats:sup>\n                      cells\/L vs. 93\u2009\u00b1\u200953 \u00d7 10\n                      <jats:sup>6<\/jats:sup>\n                      cells\/L; p\u2009&lt;\u20090.001). In AA donors, the presence of sickle cell trait (SCT; n\u2009=\u200941) did not affect CD34+ mobilization (peak CD34+ 123\u2009\u00b1\u200991 \u00d7 10\n                      <jats:sup>6<\/jats:sup>\n                      cells\/L vs. 107\u2009\u00b1\u200972 \u00d7 10\n                      <jats:sup>6<\/jats:sup>\n                      cells\/L, HbAS vs. HbAA; p\u2009=\u20090.34). Adverse events were minimal and similar across race.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>AAs demonstrated significantly better CD34 mobilization responses to G\u2010CSF than Caucasians. This was independent of other demographic and hematologic variables. Studying race\u2010associated pharmacogenomics in relation to G\u2010CSF may improve dosing strategies. Adverse event profile and CD34 mobilization were similar in AA donors with and without SCT. Our findings suggest that it would be safe to include healthy AA donors with SCT in unrelated donor registries.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.13551","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T10:02:05Z","timestamp":1462960925000},"page":"1058-1065","source":"Crossref","is-referenced-by-count":24,"title":["Hematopoietic progenitor cell mobilization is more robust in healthy African American compared to Caucasian donors and is not affected by the presence of sickle cell trait"],"prefix":"10.1111","volume":"56","author":[{"given":"Sandhya R.","family":"Panch","sequence":"first","affiliation":[{"name":"Hematology\/Transfusion Medicine National Heart, Lung and Blood Institute Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Ying","family":"Yau","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Clinical Center National Institutes of Health Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney D.","family":"Fitzhugh","sequence":"additional","affiliation":[{"name":"Hematology\/Transfusion Medicine National Heart, Lung and Blood Institute Bethesda Maryland"},{"name":"National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew M.","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Hematology\/Transfusion Medicine National Heart, Lung and Blood Institute Bethesda Maryland"},{"name":"National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Tisdale","sequence":"additional","affiliation":[{"name":"Hematology\/Transfusion Medicine National Heart, Lung and Blood Institute Bethesda Maryland"},{"name":"National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan F.","family":"Leitman","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Clinical Center National Institutes of Health Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V81.7.1960.1960"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.09.020"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904971"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009143431101"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-143677"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2005.00701.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1991.00400030063011"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-7-200704030-00004"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07335.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000046530"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2006.06.003"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2003.12.003"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.01922.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(79)90391-7"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03253.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-02-0713"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03751.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.3.850"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00151.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2003.00361.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04157.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.10.007"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404241101"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.08.031"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-10-463414"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703887"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-03-417667"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/14653240902849788"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197301042880108"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.12.3998"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.13551","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.13551","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T08:43:21Z","timestamp":1695545001000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.13551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/trf.13551"],"URL":"https:\/\/doi.org\/10.1111\/trf.13551","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5]]}}}