{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:47:35Z","timestamp":1775065655679,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,5,3]],"date-time":"2016-05-03T00:00:00Z","timestamp":1462233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Delayed hemolytic transfusion reaction (DHTR) is a life\u2010threatening condition in sickle cell disease (SCD) patients that is frequently complicated by hyperhemolysis. Antibodies resulting from antigen disparity between donors of European ancestry and patients of African ancestry are common, but situations involving antibodies not classically of clinical significance are also encountered. Anti\u2010HI is generally considered to be an innocuous naturally occurring antibody.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>We describe two cases of hyperhemolysis with anti\u2010HI and provide details of the reported cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Both SCD patients were polyimmunized and belonged to blood group B. They developed anti\u2010HI that was reactive at 37\u00b0C, after the transfusion of group O red blood cell units matched for all known and produced antibodies classically considered to be clinically significant. Both patients developed DHTR with hyperhemolysis. In the first case, a pregnant woman, a second transfusion was unavoidable and the patient died from cardiac arrest. The state of the second patient improved without the need for further transfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Three other cases of DHTR with anti\u2010HI have been described in the literature in SCD patients. The two additional cases reported here definitively demonstrate that anti\u2010HI is dangerous in SCD patients. As a result, ABO\u2010identical matching (including A1 status) must be considered in SCD patients with anti\u2010HI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13611","type":"journal-article","created":{"date-parts":[[2016,5,4]],"date-time":"2016-05-04T16:19:36Z","timestamp":1462378776000},"page":"1828-1833","source":"Crossref","is-referenced-by-count":12,"title":["Anti\u2010HI can cause a severe delayed hemolytic transfusion reaction with hyperhemolysis in sickle cell disease patients"],"prefix":"10.1111","volume":"56","author":[{"given":"Clara","family":"Ibanez","sequence":"first","affiliation":[{"name":"\u00c9tablissement Fran\u00e7ais du Sang, Ile de France, H\u00f4pital Henri Mondor"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anoosha","family":"Habibi","sequence":"additional","affiliation":[{"name":"IMRB, INSERM U955, Equipe 2: Transfusion et maladies du globule rouge Institut Mondor de Recherche Biom\u00e9dicale, UPEC Cr\u00e9teil France"},{"name":"Centre de R\u00e9f\u00e9rence des Syndromes Dr\u00e9panocytaires Majeurs, H\u00f4pital Henri Mondor, AP\u2010HP, UPEC Cr\u00e9teil"},{"name":"Laboratoire D'Excellence GR\u2010Ex F\u201075015 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armand","family":"Mekontso\u2010Dessap","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation M\u00e9dicale H\u00f4pital Henri Mondor, AP\u2010HP, UPEC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Chadebech","sequence":"additional","affiliation":[{"name":"\u00c9tablissement Fran\u00e7ais du Sang, Ile de France, H\u00f4pital Henri Mondor"},{"name":"IMRB, INSERM U955, Equipe 2: Transfusion et maladies du globule rouge Institut Mondor de Recherche Biom\u00e9dicale, UPEC Cr\u00e9teil France"},{"name":"Laboratoire D'Excellence GR\u2010Ex F\u201075015 Paris 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H\u00f4pital Henri Mondor, AP\u2010HP, UPEC Cr\u00e9teil"},{"name":"Laboratoire D'Excellence GR\u2010Ex F\u201075015 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Rieux","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de S\u00e9curit\u00e9 Transfusionnelle et d'H\u00e9movigilance H\u00f4pital Henri Mondor, AP\u2010HP Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00eblle","family":"Nataf","sequence":"additional","affiliation":[{"name":"Institut National de la Transfusion Sanguine, D\u00e9partement Centre National de r\u00e9f\u00e9rence pour les Groupes Sanguins"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Bartolucci","sequence":"additional","affiliation":[{"name":"IMRB, INSERM U955, Equipe 2: Transfusion et maladies du globule rouge Institut Mondor de Recherche Biom\u00e9dicale, UPEC Cr\u00e9teil France"},{"name":"Centre de R\u00e9f\u00e9rence des 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