{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T10:50:40Z","timestamp":1753181440437},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,6,6]],"date-time":"2016-06-06T00:00:00Z","timestamp":1465171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"High Institute for Research and Education in Transfusion Medicine"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Due to blood screening and blood donor selection, the prevalence of hepatitis C virus (HCV) is expected to be lower among blood donors compared to the general population. The effective control of blood\u2010transmitted infectious diseases should be one of the goals of public health. Thus, this case\u2010control study was conducted to evaluate the risk factors of HCV in a representative sample of blood donors in Iran.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>A case\u2010control study was conducted on HCV\u2010negative and on serologically confirmed HCV\u2010positive donors across the country from 2009 to 2013. Univariate logistic regression, multiple logistic regression, and subgroup analyses were performed to assess the risk factors in first\u2010time blood donors (FTs) and repeat blood donors (RDs) independently.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 970 cases and 1542 controls were selected from the cohort of Iranian blood donors registered in the Iran Blood Transfusion Organization. Intravenous (IV) drug abuse (OR<jats:sub>FT<\/jats:sub>, 6.42; 95% CI, 3.34\u201012.34; and OR<jats:sub>RD<\/jats:sub>, 27.62; 95% CI, 12.58\u201060.62), living with an IV drug abuser (OR<jats:sub>FT<\/jats:sub>, 3.47; 95% CI, 1.26\u20109.55; and OR<jats:sub>RD<\/jats:sub>, 6.95; 95% CI, 1.54\u201031.34), prison history (OR<jats:sub>FT<\/jats:sub>, 2.4; 95% CI, 1.48\u20103.88; and OR<jats:sub>RD<\/jats:sub>, 2.42; 95% CI, 1.38\u20104.27), sharing personal razors (OR<jats:sub>FT<\/jats:sub>, 2.00; 95% CI, 1.01\u20103.96; and OR<jats:sub>RD<\/jats:sub>, 5.62; 95% CI, 2.65\u201011.89), and medical exposure (OR<jats:sub>FT<\/jats:sub>, 1.97; 95% CI, 1.15\u20103.37; and OR<jats:sub>RD<\/jats:sub>, 2.19; 95% CI, 1.27\u20103.76) were significant independent risk factors in both types of blood donation.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The findings of this analytic study on HCV exposure in Iranian blood donors conforms to those of international studies. Behavioral and medical factors should be examined in the donor health screening process.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13660","type":"journal-article","created":{"date-parts":[[2016,6,7]],"date-time":"2016-06-07T04:07:13Z","timestamp":1465272433000},"page":"1891-1898","source":"Crossref","is-referenced-by-count":13,"title":["Risk factor analysis of hepatitis C virus seropositivity in Iranian blood donors: a case\u2010control study"],"prefix":"10.1111","volume":"56","author":[{"given":"Negar","family":"Rezaei","sequence":"first","affiliation":[{"name":"Department of Research and Education and the Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sedigheh","family":"Amini\u2010Kafiabad","sequence":"additional","affiliation":[{"name":"Department of Hematology Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine; and the Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahtab","family":"Maghsudlu","sequence":"additional","affiliation":[{"name":"Department of Research and Education and the Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Abolghasemi","sequence":"additional","affiliation":[{"name":"Shabid Beheshti University of Medical Sciences Tehran Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510310329"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i43.7025"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02087874"},{"key":"e_1_2_8_5_1","first-page":"1510","article-title":"Factors associated with hepatitis C infection among chronic HCV Egyptian patients","volume":"43","author":"W Abd El\u2010Wahab E","year":"2014","journal-title":"Iran J Public Health"},{"key":"e_1_2_8_6_1","first-page":"199","article-title":"Hepatitis C virus infection and risk factors in health\u2010care workers at Ain Shams University Hospitals, Cairo, Egypt","volume":"21","author":"Okasha O","year":"2015","journal-title":"East Mediterr Health J"},{"key":"e_1_2_8_7_1","first-page":"84","article-title":"Hepatitis C virus in Iran: epidemiology of an emerging infection","volume":"8","author":"Alavian SM","year":"2005","journal-title":"Arch Iran Med"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02622.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02245.x"},{"key":"e_1_2_8_10_1","first-page":"674","article-title":"Prevalence and trend of hepatitis C virus infection among blood donors in Iran: a systematic review and meta\u2010analysis","volume":"18","author":"Khodabandehloo M","year":"2013","journal-title":"J Res Med Sci"},{"key":"e_1_2_8_11_1","first-page":"10","article-title":"Blood safety overview in Iran","volume":"18","author":"Amini\u2010Kafiabad S.","year":"2015","journal-title":"Arch Iran Med"},{"key":"e_1_2_8_12_1","unstructured":"9.6.2 What are subgroup analyses? 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