{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T07:45:20Z","timestamp":1695800720807},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,5,30]],"date-time":"2016-05-30T00:00:00Z","timestamp":1464566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Fetal <jats:italic>RHD<\/jats:italic> genotyping allows targeted diagnostic testing, fetal surveillance, and eventually intrauterine treatment to D\u2010alloimmunized pregnant women who carry an <jats:italic>RHD+<\/jats:italic> fetus. However, false\u2010positive and false\u2010negative results of noninvasive prenatal fetal <jats:italic>RHD<\/jats:italic> genotyping have been described due to a variety of causes. In this case report we present two cases where noninvasive fetal <jats:italic>RHD<\/jats:italic> typing was complicated by a previous bone marrow transplantation (BMT).<\/jats:p><\/jats:sec><jats:sec><jats:title>CASE REPORT<\/jats:title><jats:p>We describe two women with a history of allogeneic BMT in early childhood. Both were born D+ and received a transplant of their D\u2013 male sibling. Anti\u2010D were detected during pregnancy in one of them. The biologic father of this pregnancy was D+. In both cases polymerase chain reaction procedures specific for <jats:italic>RHD<\/jats:italic> on maternal plasma DNA were positive whereas a D\u2013 neonate was born in one case (Case 1).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>False\u2010positive results of noninvasive fetal <jats:italic>RHD<\/jats:italic> genotyping occur in D+ women transplanted with marrow of a D\u2013 donor, due to circulating cell\u2010free DNA originating from nonhematopoietic tissue. The cases highlight that health care professionals and laboratories should be aware that allogeneic BMT can be a cause for false\u2010positive results in fetal <jats:italic>RHD<\/jats:italic> genotyping with cell\u2010free DNA in maternal plasma, and likewise the wrong fetal sex can be reported in the case of a male donor and a female fetus. Based on one of the cases we also recommend giving D\u2013 blood products to young female patients who receive a BMT of D\u2013 donors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13669","type":"journal-article","created":{"date-parts":[[2016,5,30]],"date-time":"2016-05-30T14:36:42Z","timestamp":1464619002000},"page":"2122-2126","source":"Crossref","is-referenced-by-count":1,"title":["Fetal <i>RHD<\/i> genotyping after bone marrow transplantation"],"prefix":"10.1111","volume":"56","author":[{"given":"Florentine F.","family":"Thurik","sequence":"first","affiliation":[{"name":"Department of Experimental Immunohematology, Amsterdam and Landsteiner Laboratory, Academic Medical Center Sanquin, University of Amsterdam Amsterdam The Netherlands"},{"name":"Division Woman and Baby, Department of Obstetrics University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Godelieve C.M.L.","family":"Page\u2010Christiaens","sequence":"additional","affiliation":[{"name":"Division Woman and Baby, Department of Obstetrics University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aicha","family":"Ait Soussan","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunohematology, Amsterdam and Landsteiner Laboratory, Academic Medical Center Sanquin, University of Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter C.","family":"Ligthart","sequence":"additional","affiliation":[{"name":"Department of Immunohematology Diagnostic Services Sanquin Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goedele M.A.F.","family":"Cheroutre","sequence":"additional","affiliation":[{"name":"Department of Immunohematology Diagnostic Services Sanquin Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernadette","family":"Bossers","sequence":"additional","affiliation":[{"name":"Department of Immunohematology Diagnostic Services Sanquin Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbera","family":"Veldhuisen","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunohematology, Amsterdam and Landsteiner Laboratory, Academic Medical Center Sanquin, University of Amsterdam Amsterdam The Netherlands"},{"name":"Department of Immunohematology Diagnostic Services Sanquin Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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