{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:18:14Z","timestamp":1788347894388,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T00:00:00Z","timestamp":1465776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Transfusion\u2010transmitted malaria (TTM) is a well\u2010known, though rare, entity in the United States with only 100 cases previously reported. With no Food and Drug Administration\u2013approved screening tests of donated blood for malaria in the United States, prevention relies solely on deferral of the highest\u2010risk donors. We present a case of TTM not preventable by these guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>CASE REPORT<\/jats:title><jats:p>A 76\u2010year\u2010old male presented with fever, hypotension, tachycardia, and a urinalysis consistent with a urinary tract infection. He was admitted to the intensive care unit and initiated on broad\u2010spectrum antibiotics. On Hospital Day 2, he was incidentally found to have intraerythrocytic parasites on a peripheral smear, identified as <jats:italic>Plasmodium malariae<\/jats:italic> by polymerase chain reaction and was treated successfully with atovaquone\u2010proguanil. The patient had no recent foreign travel or exposure to malaria but had received 15\u00a0units of blood products in the past 6\u00a0years. Index samples from the 10 most recent units were obtained, with one testing positive for <jats:italic>P.\u00a0malariae<\/jats:italic> via serology. The donor was a 20\u2010year\u2010old male who immigrated to the United States from Liberia at the age of 5 with no subsequent travel or exposure to malaria.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>A review of current literature demonstrated that 71% of TTM cases occur from imperfect application of the current deferral guidelines. In this case, however, 15\u00a0years had elapsed between the donor's immigration and the transmission of the disease, placing him well outside any current deferral period. As such, the case demonstrates the need for continued development of highly sensitive and cost\u2010effective laboratory screening for high\u2010risk donors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13680","type":"journal-article","created":{"date-parts":[[2016,6,14]],"date-time":"2016-06-14T07:12:03Z","timestamp":1465888323000},"page":"2221-2224","source":"Crossref","is-referenced-by-count":22,"title":["Transfusion\u2010transmitted malaria not preventable by current blood donor screening guidelines: a case report"],"prefix":"10.1111","volume":"56","author":[{"given":"Arthur","family":"Holtzclaw","sequence":"first","affiliation":[{"name":"Department of Internal Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zorana","family":"Mrsic","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Managbanag","sequence":"additional","affiliation":[{"name":"Department of Pathology and Area Lab Services Dwight D. Eisenhower Army Medical Center Ft Gordon Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Calvano","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Colombo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,13]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"The 2011 national blood collection and utilization survey report","author":"Whitaker BI","year":"2011"},{"key":"e_1_2_6_3_1","first-page":"132","article-title":"Transfusion for pernicious anaemia: two cases","volume":"53","author":"Woolsey G.","year":"1911","journal-title":"Ann Surg"},{"key":"e_1_2_6_4_1","volume-title":"World malaria report","year":"2014"},{"key":"e_1_2_6_5_1","unstructured":"Guidance for Industry Recommendations for Donor Questioning Deferral Reentry and Product Management to Reduce the Risk of Transfusion\u2010Transmitted Malaria [Internet].2013[cited 2016 Apr 29]. Available from:http:\/\/www.fda.gov\/BiologicsBloodVaccines\/GuidanceComplianceRegulatoryInformation\/Guidances\/Blood\/ucm077061.htm."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02290.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01292.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200106283442603"},{"key":"e_1_2_6_9_1","first-page":"1","article-title":"Malaria surveillance\u2014United States, 2011","volume":"62","author":"Cullen KA","year":"2013","journal-title":"MMWR Surveill Summ"},{"key":"e_1_2_6_10_1","volume-title":"Traveler's malaria, locally\u2010transmitted malaria and transfusion\u2010transmitted malaria in the United States [Internet]","author":"Parise ME.","year":"2006"},{"key":"e_1_2_6_11_1","volume-title":"Malaria in the United States military and its implications for the safety of the blood supply? [Internet]","author":"Ockenhouse CF.","year":"2006"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652406776055221"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2006.00733.x"},{"key":"e_1_2_6_14_1","first-page":"162","article-title":"Immunological testing for malaria and blood donor deferral: the experience of the Ca' Granda Polyclinic Hospital in Milan","volume":"9","author":"Grande R","year":"2011","journal-title":"Blood Transfus"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2009.01251.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-10-340"},{"key":"e_1_2_6_17_1","volume-title":"Screening donated blood for transfusion\u2010transmissible infections: recommendations","year":"2010"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.13680","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.13680","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/trf.13680","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.13680","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T08:16:40Z","timestamp":1694420200000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.13680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,13]]},"references-count":16,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/trf.13680"],"URL":"https:\/\/doi.org\/10.1111\/trf.13680","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,13]]}}}