{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:18:24Z","timestamp":1790806704994,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T00:00:00Z","timestamp":1466467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Zika virus (ZIKV) is an emerging arthropod\u2010borne flavivirus transmitted by <jats:italic>Aedes<\/jats:italic> mosquitoes. Recent commentaries regarding ZIKV routes of transmission describe a potential transmission by transfusion. Herein, we report a probable case of transfusion\u2010transmitted ZIKV infection through a platelet transfusion that was detected from postdonation information.<\/jats:p><\/jats:sec><jats:sec><jats:title>CASE REPORT<\/jats:title><jats:p>A blood donor made a voluntary telephone report to the blood donor facility 3 days after donation and informed the facility of a febrile illness (fever, malaise, and headaches). Due to the ongoing dengue epidemic, the initial clinical investigation included dengue among other possible diagnoses. The serology and molecular laboratory results excluded dengue infection. However, stored samples from the donation were positive for ZIKV on reverse transcription\u2010polymerase chain reaction (RT\u2010PCR) analysis. A retrospective investigation demonstrated that the platelet concentrate, which was part of a pool, had been transfused after a liver transplantation. A physician had evaluated the patient 4 days after surgery. Laboratory investigation showed enzyme\u2010linked immunosorbent assay results that were negative for dengue immunoglobulin M antibodies; however, the results were positive for hemagglutination inhibition antibodies against flavivirus. ZIKV RT\u2010PCR and virus isolation analyses in cell cultures from recipient serum were both positive. The sequencing confirmed ZIKV in the donor and patient samples. Ten partial nucleotide sequences from the ZIKV strain that were detected in the donor were aligned and compared with the ZIKV genome detected in the recipient, revealing a 99.8% homology between the two strains.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>This is a case of probable transmission of ZIKV through blood transfusion. The patient had been transfused with the blood product from an infected donor, most likely in the incubation period after ZIKV infection but prior to clinical disease onset. This report emphasizes the importance of postdonation information and recipient investigations during outbreaks of potentially blood\u2010borne infections.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13681","type":"journal-article","created":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T04:04:43Z","timestamp":1466654683000},"page":"1684-1688","source":"Crossref","is-referenced-by-count":216,"title":["Probable transfusion\u2010transmitted Zika virus in Brazil"],"prefix":"10.1111","volume":"56","author":[{"given":"Maria L.","family":"Barjas\u2010Castro","sequence":"first","affiliation":[{"name":"Hematology and Transfusion Center, Universidade Estadual de Campinas\u2010UNICAMP Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo N.","family":"Angerami","sequence":"additional","affiliation":[{"name":"Section of Hospital Epidemiology Hospital of Clinics, Universidade Estadual de Campinas\u2010UNICAMP Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana S.","family":"Cunha","sequence":"additional","affiliation":[{"name":"Instituto Adolfo Lutz S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akemi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Instituto Adolfo Lutz S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana S.","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Instituto Adolfo Lutz S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iray M.","family":"Rocco","sequence":"additional","affiliation":[{"name":"Instituto Adolfo Lutz S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Y.","family":"Maeda","sequence":"additional","affiliation":[{"name":"Instituto Adolfo Lutz S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda G.S.","family":"Vasami","sequence":"additional","affiliation":[{"name":"Instituto Adolfo Lutz S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gizelda","family":"Katz","sequence":"additional","affiliation":[{"name":"Infectious Diseases Surveillance Center \u201cProf. Alexandre Vranjac\u201d\/Disease Control Coordination S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilka F.S.F.","family":"Boin","sequence":"additional","affiliation":[{"name":"Clinical Medical Department, Faculty of Medical Sciences, Universidade Estadual de Campinas\u2010UNICAMP Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel S.B.","family":"Stucchi","sequence":"additional","affiliation":[{"name":"Clinical Medical Department, Faculty of Medical Sciences, Universidade Estadual de Campinas\u2010UNICAMP Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari\u00e2ngela R.","family":"Resende","sequence":"additional","affiliation":[{"name":"Section of Hospital Epidemiology Hospital of Clinics, Universidade Estadual de Campinas\u2010UNICAMP Campinas SP Brazil"},{"name":"Clinical Medical Department, Faculty of Medical Sciences, Universidade Estadual de Campinas\u2010UNICAMP Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danillo L.A.","family":"Esposito","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas de Ribeir\u00e3o Preto, Ribeir\u00e3o Preto, Universidade Estadual de S\u00e3o Paulo  SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato P.","family":"de Souza","sequence":"additional","affiliation":[{"name":"Instituto Adolfo Lutz S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedito A.","family":"da 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FDA guidance: recommendations for donor screening deferral and product management to reduce the risk of transfusion\u2010transmission of Zika virus. 2016 [cited 2016 Jun 16]. Available from:http:\/\/www.fda.gov\/downloads\/BiologicsBloodVaccines\/GuidanceComplianceRegulatoryInformation\/Guidances\/Blood\/UCM486360.pdf.2016."},{"key":"e_1_2_6_12_1","article-title":"Monitoramento dos casos de dengue e febre de chikungunya\u2010Semana Epidemiol\u00f3gica 30, 2015","volume":"46","author":"Minist\u00e9rio da Sa\u00fade, Secretaria de Vigil\u00e2ncia em Sa\u00fade.","year":"2015","journal-title":"Bol Epidemiol\u00f3gico"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2015.10.004"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1408.080287"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.00032-16"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i657"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tracli.2013.03.008"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030969"},{"key":"e_1_2_6_19_1","first-page":"170","article-title":"Review of dengue fever cases in Hong Kong during 1998 to 2005","volume":"14","author":"Chuang V","year":"2008","journal-title":"Hong Kong Med J"},{"key":"e_1_2_6_20_1","first-page":"34","article-title":"Transfusion\u2010related transmission of yellow fever vaccine virus\u2010California, 2009","volume":"59","author":"Centers for Disease Control and Prevention (CDC).","year":"2010","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_6_21_1","unstructured":"National Healthcare Safety Network [NHSN]. NHSN Biovigilance Component Hemovigilance Module Surveillance Protocol 2016; version 2.2. [cited 2016 Jun 16]. 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