{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:27:50Z","timestamp":1740126470193,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T00:00:00Z","timestamp":1468195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The ABO blood group is a major determinant in living donor kidney transplantation since AB antigens are expressed on renal tissue. Little attention has been directed to the ABH\u2010secretor status of the donor kidney. As renal tissue is capable of secreting soluble ABH antigens in secretors, we examined the influence of the ABH\u2010secretor status of kidney donors on outcome in ABO\u2010mismatched living donor kidney transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>We retrospectively analyzed all patients who underwent ABO\u2010mismatched kidney transplantation at the University Hospital Basel from September 2005 to October 2013. The ABH\u2010secretor status was determined in all donors by molecular genetic analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Of all 55 patients who received transplants, we excluded all patients with donor\u2010specific antibodies (n\u00a0=\u00a04). Forty\u2010one donors were secretors (78%) and 11 were nonsecretors (22%). Recipients of ABH\u2010secretor donor organs showed a significantly higher glomerular filtration rate throughout the first 6 months posttransplant, whereas no significant influence on posttransplant anti\u2010A\/B titers was found. Regression analysis revealed a significant impact on humoral rejection, whereas not on vascular or interstitial rejection in protocol kidney biopsies.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The donor ABH\u2010secretor status may have an influence on early posttransplant renal function in patients undergoing ABO\u2010mismatched living donor kidney transplantation. Further prospective studies with long\u2010term follow\u2010up are needed to elucidate involved pathomechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13711","type":"journal-article","created":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T09:30:15Z","timestamp":1468229415000},"page":"2355-2361","source":"Crossref","is-referenced-by-count":2,"title":["Impact of donor ABH\u2010secretor status in ABO\u2010mismatched living donor kidney transplantation"],"prefix":"10.1111","volume":"56","author":[{"given":"Beatrice","family":"Drexler","sequence":"first","affiliation":[{"name":"Department of Haematology University Hospital Basel Basel"},{"name":"Blood Transfusion Centre, Swiss Red Cross Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Holbro","sequence":"additional","affiliation":[{"name":"Department of Haematology University Hospital Basel Basel"},{"name":"Blood Transfusion Centre, Swiss Red Cross Basel, 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