{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:26:37Z","timestamp":1790627197871,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,8,13]],"date-time":"2016-08-13T00:00:00Z","timestamp":1471046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Hepatitis E virus (HEV) Genotype 3 (G3) infection is a zoonosis that may be transmitted during the acute phase by transfusion. The aim of this study was to determine the incidence of HEV and seroprevalence among Irish blood donors.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>Anonymized samples from 1076 donations collected in 2012 were tested for HEV immunoglobulin (Ig)G using the Wantai enzyme\u2010linked immunosorbent assay. A total of 24,985 anonymized donations collected between December 2013 and June 2014 were individually tested for HEV RNA using the Procleix HEV assay; reactive donations were confirmed by an in\u2010house real\u2010time polymerase chain reaction (PCR) test.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Seroprevalence for anti\u2010IgG was 5.3% (95% confidence interval [CI], 4.0%\u20106.8%), ranging from 1.1% in the 18\u2010 to 29\u2010years age group to 33.3% in males over 60 years. HEV RNA screening of 24,985 samples yielded five PCR\u2010confirmed donations (1:4997, 0.02%; 95% CI, 0.0065%\u20100.0467%), only one of which was serologically reactive (HEV IgM reactive only). Viral loads ranged from 10 to 44,550 IU\/mL. Genotype analysis on three samples identified HEV G3 virus. Four of the five viremic donations were from donors in the 18\u2010 to 29\u2010years age group (p\u00a0=\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Seroprevalence for anti\u2010HEV IgG was low compared to some European countries, but 1 in 5000 donations was viremic. Viremia was predominantly in younger Irish donors. After Department of Health approval the Irish Blood Transfusion Service implemented individual blood donation HEV RNA screening initially for a 3\u2010year period from January 2016.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13757","type":"journal-article","created":{"date-parts":[[2016,8,13]],"date-time":"2016-08-13T13:26:43Z","timestamp":1471094803000},"page":"2868-2876","source":"Crossref","is-referenced-by-count":58,"title":["Hepatitis E virus infection in the Irish blood donor population"],"prefix":"10.1111","volume":"56","author":[{"given":"Joan","family":"O'Riordan","sequence":"first","affiliation":[{"name":"Irish Blood Transfusion Service, National Blood Centre Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Boland","sequence":"additional","affiliation":[{"name":"Irish Blood Transfusion Service, National Blood Centre Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padraig","family":"Williams","sequence":"additional","affiliation":[{"name":"Irish Blood Transfusion Service, National Blood Centre Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Donnellan","sequence":"additional","affiliation":[{"name":"Irish Blood Transfusion Service, National Blood Centre Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris M.","family":"Hogema","sequence":"additional","affiliation":[{"name":"Departments of Blood\u2010borne Infections and Virology Sanquin Research and Diagnostic Services Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samreen","family":"Ijaz","sequence":"additional","affiliation":[{"name":"Blood Borne Virus Unit, Virus Reference Department National Infection Service, Public Health England London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Irish Blood Transfusion Service, National Blood Centre Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1501.080296"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60595-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2007.00858.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.02.050"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-03-492363"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0903778"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12285"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13402"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES2013.18.31.20550"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12056"},{"key":"e_1_2_8_12_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S2055-6640(20)31147-X","article-title":"Hepatitis E virus in developed countries: one of the most successful zoonotic viral diseases in human history?","volume":"1","author":"Dalton HR","year":"2015","journal-title":"J Virus Erad"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61034-5"},{"key":"e_1_2_8_14_1","first-page":"214","article-title":"Transfusion transmission of hepatitis E virus by solvent\u2010detergent inactivated plasma","author":"Assal A","year":"2013","journal-title":"Transfusion"},{"key":"e_1_2_8_15_1","unstructured":"Human plasma (pooled and treated for virus inactivation) monograph 1646. 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