{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T14:42:16Z","timestamp":1781707336182,"version":"3.54.5"},"reference-count":7,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T00:00:00Z","timestamp":1472083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN26820041717"],"award-info":[{"award-number":["HHSN26820041717"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The frequency of positive test results for transfusion\u2010transmitted infections (TTIs) among blood donors is an important index of safety; thus, appropriate monitoring is critical, particularly when there are changes in policies affecting donor suitability.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>Testing algorithms from three large blood systems were reviewed and consensus definitions for a surveillance\u2010positive result for hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), and human T\u2010cell lymphotropic virus (HTLV) established. In addition, information on each donation, including donor demographics and location, was collected. Combined data were analyzed to characterize the epidemiology of TTIs by person, place, and time.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Data from 14.8 million donations were collected for 2011 to 2012, representing more than 50% of the US blood supply. Surveillance\u2010positive rates per 10,000 donations were as follows: HBV, 0.76; HCV, 2.0; HIV, 0.28; and HTLV 0.34. Rates did not vary between the 2 years, although there was variation within a year. With the exception of HTLV, rates were higher among males, and all rates were higher among first\u2010time donations. Window\u2010period donations (those positive only in nucleic acid tests) were infrequent (HBV, 13; HCV, 60; HIV, 14) during the 2\u2010year period. Frequencies of surveillance\u2010positive results varied by donor age and residence location.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>We demonstrated that standardized data from multiple major US blood systems can be combined and analyzed for change. However, TTI frequencies are low, impacting their sensitivity to change. Furthermore, observed fluctuations in TTI frequencies may be secondary to changes in blood donor demographics rather than necessarily reflecting the immediate impact of policy modification.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13759","type":"journal-article","created":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T08:15:04Z","timestamp":1472112904000},"page":"2781-2789","source":"Crossref","is-referenced-by-count":37,"title":["Development of a multisystem surveillance database for transfusion\u2010transmitted infections among blood donors in the United States"],"prefix":"10.1111","volume":"56","author":[{"given":"Roger Y.","family":"Dodd","sequence":"first","affiliation":[{"name":"Scientific Affairs, Holland Laboratory, American Red Cross Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward P.","family":"Notari","sequence":"additional","affiliation":[{"name":"Scientific Affairs, Holland Laboratory, American Red Cross Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Nelson","sequence":"additional","affiliation":[{"name":"Scientific Affairs, Holland Laboratory, American Red Cross Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Foster","sequence":"additional","affiliation":[{"name":"Scientific Affairs American Red Cross Gaithersburg Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Krysztof","sequence":"additional","affiliation":[{"name":"Scientific Affairs American Red Cross Gaithersburg Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanna","family":"Kaidarova","sequence":"additional","affiliation":[{"name":"Blood Systems Research Institute San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Milan\u2010Benson","sequence":"additional","affiliation":[{"name":"New York Blood Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra A.","family":"Kessler","sequence":"additional","affiliation":[{"name":"New York Blood Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth H.","family":"Shaz","sequence":"additional","affiliation":[{"name":"New York Blood Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1130-4643","authenticated-orcid":false,"given":"Farnaz","family":"Vahidnia","sequence":"additional","affiliation":[{"name":"Blood Systems Research Institute San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Custer","sequence":"additional","affiliation":[{"name":"Blood Systems Research Institute San Francisco California"},{"name":"Department of Laboratory Medicine University of California at San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Stramer","sequence":"additional","affiliation":[{"name":"Scientific Affairs American Red Cross Gaithersburg Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the NHLBI Retrovirus Epidemiology Donor Study (REDS)\u2010II","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2011.07.007"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040085"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit497"},{"key":"e_1_2_7_5_1","unstructured":"Revised recommendations for reducing the risk of human immunodeficiency virus transmission by blood and blood products: guidance for industry [Internet]. Silver Spring (MD):U.S. Food and Drug Administration;2015[cited 2016 May 2]. Available from:http:\/\/www.fda.gov\/downloads\/BiologicsBloodVaccines\/GuidanceComplianceRegulatoryInformation\/Guidances\/Blood\/UCM446580.pdf."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13632"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12213"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12951"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.13759","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.13759","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T13:56:11Z","timestamp":1695563771000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.13759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,25]]},"references-count":7,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/trf.13759"],"URL":"https:\/\/doi.org\/10.1111\/trf.13759","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,25]]}}}