{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:27:50Z","timestamp":1740126470800,"version":"3.37.3"},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T00:00:00Z","timestamp":1473206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008173","name":"Intermountain Research and Medical Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008173","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Our previous retrospective study suggested that red blood cell (RBC) transfusion of preterm neonates can be associated with an increase in bilirubin, but this has not been tested prospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>We studied neonates before and after RBC transfusions, recording serial bilirubin levels and whether they qualified for phototherapy. Because lysed RBCs release plasma\u2010free hemoglobin (Hb), a precursor to bilirubin, we also measured plasma free Hb and bilirubin from the donor blood.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>We studied 50 transfusions given to 39 neonates. Gestation ages of transfused neonates, at birth, were 26 (24\u201029) weeks (median [interquartile range]); birthweights were 750 (620\u20101070) g. The study transfusion was given on Day of Life 9.9 (3.4\u201019.2). In 20% (10\/50) phototherapy was being administered at the beginning of and during the transfusion. In these patients neither the 4\u2010 to 6\u2010 nor the 24\u2010 to 36\u2010hour\u2010posttransfusion bilirubin levels were significantly higher than before transfusion. However, in 30% of the others (12\/40) phototherapy was started (or restarted) after the transfusion and 15% had a posttransfusion bilirubin increase of at least 2.5 mg\/dL. These neonates received donor blood with a higher plasma\u2010free Hb (p\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Neonates commonly qualify for phototherapy after transfusion. A minority (15% in this series) have a posttransfusion bilirubin increase of at least 2.5 mg\/dL. We speculate that neonates qualifying for a RBC transfusion, who are judged to be at high risk for bilirubin\u2010induced neurotoxicity, might benefit from checking their serum bilirubin level after the transfusion and providing donor blood with low plasma\u2010free Hb levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13761","type":"journal-article","created":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T15:18:39Z","timestamp":1473261519000},"page":"2727-2731","source":"Crossref","is-referenced-by-count":0,"title":["Bilirubin levels and phototherapy use before and after neonatal red blood cell transfusions"],"prefix":"10.1111","volume":"56","author":[{"given":"Patrick D.","family":"Carroll","sequence":"first","affiliation":[{"name":"Women and Newborns Program Dixie Regional Medical Center St George Utah"},{"name":"Neonatology Dixie Regional Medical Center St George Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert D.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Women and Newborns Program Dixie Regional Medical Center St George Utah"},{"name":"Department of Pediatrics University of Utah School of Medicine Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vickie L.","family":"Baer","sequence":"additional","affiliation":[{"name":"Women and Newborns Program Dixie Regional Medical Center St George Utah"},{"name":"Neonatology McKay Dee Hospital Center Ogden Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark J.","family":"Sheffield","sequence":"additional","affiliation":[{"name":"Women and Newborns Program Dixie Regional Medical Center St George Utah"},{"name":"Neonatology McKay Dee Hospital Center Ogden Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erick","family":"Gerday","sequence":"additional","affiliation":[{"name":"Women and Newborns Program Dixie Regional Medical Center St George Utah"},{"name":"Neonatology Utah Valley Regional Medical Center Provo Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah J.","family":"Ilstrup","sequence":"additional","affiliation":[{"name":"Women and Newborns Program Dixie Regional Medical Center St George Utah"},{"name":"Transfusion Medicine Services Intermountain Healthcare Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2009.10.004"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2011.02.005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.134056"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2010.08.001"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12716"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2008.23"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02823.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03394.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.114.1.297"},{"key":"e_1_2_7_11_1","first-page":"726","article-title":"Neonatal bilirubin 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