{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T19:30:15Z","timestamp":1705433415700},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,8,21]],"date-time":"2016-08-21T00:00:00Z","timestamp":1471737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"\u201cProjets Recherche et D\u00e9veloppement\u201d from the Geneva University Hospitals and by the Department of Anesthesiology, Pharmacology, and Intensive Care, Geneva University Hospitals, Geneva, Switzerland"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Prasugrel provides rapid and intense inhibition of platelet aggregation combined with an increased risk of bleeding. We evaluated the efficacy and safety of platelet transfusion to reduce blood loss after a prasugrel loading dose in a rabbit model.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>Thirty\u2010five rabbits were randomized into five groups: \u201ccontrol\u201d (saline plus physiological buffer), \u201cno\u2010transfusion\u201d (prasugrel plus physiological buffer), \u201cplatelet low dose\u201d (prasugrel loading dose plus transfusion with a platelet count increase &lt;80\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L), \u201cplatelet intermediate dose\u201d (prasugrel loading dose plus transfusion with a platelet count increase 80\u2010120\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L), and \u201cplatelet high dose\u201d (prasugrel loading dose plus transfusion with a platelet count increase \u2265120\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L). Na\u00efve, washed human platelets in physiological buffer were transfused before bleeding was induced. Sequentially, a stenosis and an injury were carried out on the carotid artery to induce cyclic thrombotic occlusions. Ultimately, liver sections were performed to evaluate the primary endpoint of blood loss monitored for 15 minutes.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Blood loss in the \u201ccontrol\u201d group was 3.16 g\/kg (inerquartile range [IQR] [4.79\u20109.15]) and was increased in the \u201cno\u2010transfusion\u201d group to 6.15 g\/kg (IQR [4.79\u20109.15]; p\u2009&lt;\u20090.02). There was a gradual trend across the three transfusion groups toward less bleeding, and the highest dose of platelet transfusion significantly decreased prasugrel\u2010induced blood loss (3.05 g\/kg; IQR [2.55\u20103.56]; p\u2009=\u20090.006). Platelet aggregation was significantly but only partially restored in the latter group. Regarding safety, platelet transfusion was not associated with an increase in thrombotic events regardless of the dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>In this animal model, platelet transfusion aiming for a platelet count increase of at least 120\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L was necessary to correct prasugrel\u2010related bleeding.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13765","type":"journal-article","created":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T03:28:40Z","timestamp":1471836520000},"page":"2618-2626","source":"Crossref","is-referenced-by-count":2,"title":["Correction of prasugrel\u2010related bleeding by prophylactic transfusion of human platelets in a rabbit model"],"prefix":"10.1111","volume":"56","author":[{"given":"Fanny","family":"Bonhomme","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Pharmacology, and Intensive Care, Geneva University Hospitals Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Godier","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine Fondation Opthalmologique Adolphe de Rothschild"},{"name":"Facult\u00e9 de Pharmacie INSERM UMR\u2010S1140, Universit\u00e9 Paris Descartes"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles Marc","family":"Samama","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de Pharmacie INSERM UMR\u2010S1140, Universit\u00e9 Paris Descartes"},{"name":"Department of Anesthesiology and Intensive Care Medicine Department of Anesthesiology and Intensive Care Medicine, Cochin University Hospital, Assistance Publique\u2010Hopitaux de Paris, Universit\u00e9 Paris Descartes Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Lecompte","sequence":"additional","affiliation":[{"name":"Division of Haematology Geneva University 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