{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:51:05Z","timestamp":1759161065827},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T00:00:00Z","timestamp":1473379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Incompatibility between parental platelet (PLT) antigens may lead to sensitization of mother and development of fetal and neonatal alloimmune thrombocytopenia (FNAIT) resulting in fetal thrombocytopenia. Intravenous immunoglobulin (IVIG) with or without prednisone is the most effective, evidence\u2010based antenatal treatment for subsequent FNAIT\u2010affected pregnancies. IVIG infusion causes hemolysis in other settings, the degree depending upon patient blood groups (BGs).<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>In <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link> NCT00194987, 102 pregnant women received randomized antenatal treatment: Arm A received 2\u00a0g\/kg\/week IVIG; Arm B received 1 g\/kg\/week IVIG\u2009+\u20090.5 mg\/kg\/day prednisone. This post hoc analysis explored BG and anemia in 69 FNAIT mothers treated with Arm A or Arm B without salvage treatment to explore the effects of IVIG and steroid treatment on development of anemia in these women. Mothers whose treatment changed, for example, those with insufficient or unknown fetal PLT response who received salvage therapy, were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>For Arm A, 17 of 21 (hemoglobin [Hb]\u00a0&lt;\u00a010 g\/dL) mothers with anemia but only three of 15 mothers without anemia had BG\u2010A and\/or BG\u2010B (p\u00a0=\u00a00.0005). BG was unrelated to anemia in Arm B; only nine of 33 Arm B mothers became anemic during treatment. The mean decrease in Hb level in women with BG\u2010non\u2010O was 1.9\u00a0g\/dL and in women with BG\u2010O was 1.1 g\/dL (p\u00a0=\u00a00.004). Anemia was not caused by iron deficiency; the lowest mean corpuscular volume was 79.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>FNAIT women with BG\u2010non\u2010O more frequently develop anemia secondary to high\u2010dose IVIG infusion (2\u00a0g\/kg\/week), quite possibly from isohemagglutinin\u2010mediated hemolysis; maternal Hb requires monitoring. IVIG at 1\u00a0g\/kg\/week did not cause anemia in women with BG\u2010non\u2010O; concomitant prednisone likely alleviated the IVIG effect. Maternal BG could influence selection of antenatal treatment for FNAIT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13779","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T15:08:37Z","timestamp":1473433717000},"page":"2449-2454","source":"Crossref","is-referenced-by-count":8,"title":["Blood group A mothers are more likely to develop anemia during antenatal intravenous immunoglobulin treatment of fetal and neonatal alloimmune thrombocytopenia"],"prefix":"10.1111","volume":"56","author":[{"given":"Madhavi","family":"Lakkaraja","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Hematology Weill Medical College of Cornell University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny C.","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Hematology Weill Medical College of Cornell University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen C.","family":"Manotas","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Hematology Weill Medical College of Cornell University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl A.","family":"Vinograd","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Hematology Weill Medical College of Cornell University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Polina","family":"Ferd","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Hematology Weill Medical College of Cornell University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Gabor","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Hematology Weill Medical College of Cornell University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Wissert","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Hematology Weill Medical College of Cornell University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard L.","family":"Berkowitz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Columbia University Medical Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice G.","family":"McFarland","sequence":"additional","affiliation":[{"name":"Platelet and Neutrophil Immunology Laboratory Blood Center of Wisconsin Milwaukee Wisconsin"},{"name":"Department of Medicine, Division of Hematology\u2010Oncology Medical College of Wisconsin Wauwatosa Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James B.","family":"Bussel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Hematology Weill Medical College of Cornell University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)91733-9"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12235"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31823403f4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000270302.80336.dd"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.08.033"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04540709"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13554-014-0016-2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01721.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2011.11.004"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2005.00670.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199709)20:9<1142::AID-MUS8>3.0.CO;2-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2006.03.003"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1992.32893032099.x"},{"key":"e_1_2_8_15_1","unstructured":"CDC criteria for anemia in children and childbearing\u2010aged women. MMWR1989;38:400\u20134."},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181809c0d"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90112-4"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-0502(03)00012-0"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-198821000-00012"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.1995.tb03339.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.06.013"},{"key":"e_1_2_8_22_1","first-page":"67","article-title":"Antenatal treatment of alloimmune thrombocytopenia","volume":"80","author":"Lynch L","year":"1992","journal-title":"Obstet Gynecol"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000192404.25780.68"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.03.011"},{"key":"e_1_2_8_25_1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/AOG.0b013e3182765c63","article-title":"Maternal hemolysis after intravenous immunoglobulin treatment in fetal and neonatal alloimmune thrombocytopenia","volume":"121","author":"Rink BD","year":"2013","journal-title":"Obstet Gynecol"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1205644"},{"key":"e_1_2_8_27_1","first-page":"617","article-title":"Anti\u2010red blood cell antibodies, free light chains, and antiphospholipid antibodies in intravenous immunoglobulin preparations","volume":"15","author":"Sakem B","year":"2013","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/128.Supplement_1.S176"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.13779","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.13779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T09:18:46Z","timestamp":1695547126000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.13779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,9]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/trf.13779"],"URL":"https:\/\/doi.org\/10.1111\/trf.13779","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,9]]}}}