{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T07:53:08Z","timestamp":1790322788842,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,9,25]],"date-time":"2016-09-25T00:00:00Z","timestamp":1474761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grifols"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Hepatitis E virus (HEV) poses a risk to transfusion safety. In Australia, locally acquired HEV is rare and cases are mainly reported in travelers returning from countries endemic for HEV. The risk posed by HEV to transfusion safety in Australia is unknown; therefore, we aimed to measure the rate of current HEV infection in Australian blood donations.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>A total of 14,799 blood donations were tested for HEV RNA by transcription\u2010mediated amplification, with confirmatory testing by reverse transcription\u2013polymerase chain reaction. Viral load quantification and phylogenetic analysis was performed on HEV RNA\u2013positive samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>One (0.0068%; 95% confidence interval [CI], 0.0002%\u20100.0376%) sample was confirmed positive for HEV RNA, resulting in a risk of collecting a HEV\u2010viremic donation of 1 in 14,799 (95% CI, 1 in 584,530 to 1 in 2,657). The viral load in this sample was approximately 15,000 IU\/mL, and it was determined to be Genotype 3.<\/jats:p><\/jats:sec><jats:sec><jats:title>DISCUSSION<\/jats:title><jats:p>Our finding of 1 in 14,799 Australian donations positive for HEV RNA is lower than that from many other developed countries; this is consistent with the relatively low seroprevalence in Australia. As this HEV RNA\u2013positive sample was Genotype 3, it seems likely that this infection was acquired through zoonotic transmission, either within Australia or overseas in a developed nation. HEV has the potential to pose a risk to transfusion safety in Australia; however, additional, larger studies are required to quantify the magnitude of this risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13799","type":"journal-article","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T04:06:43Z","timestamp":1474862803000},"page":"3086-3093","source":"Crossref","is-referenced-by-count":30,"title":["Hepatitis E virus RNA in Australian blood donations"],"prefix":"10.1111","volume":"56","author":[{"given":"Ashish C.","family":"Shrestha","sequence":"first","affiliation":[{"name":"Research and Development The University of Queenslan Brisbane Queensland Australia"},{"name":"School of Medicine The University of Queenslan Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.P.","family":"Flower","sequence":"additional","affiliation":[{"name":"Research and Development The University of Queenslan Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive R.","family":"Seed","sequence":"additional","affiliation":[{"name":"Medical Services Australian Red Cross Blood Servic Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Keller","sequence":"additional","affiliation":[{"name":"Medical Services Australian Red Cross Blood Servic Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Harley","sequence":"additional","affiliation":[{"name":"Medical Services Australian Red Cross Blood Servic Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiu\u2010Tat","family":"Chan","sequence":"additional","affiliation":[{"name":"Medical Services Australian Red Cross Blood Servic Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Hoad","sequence":"additional","affiliation":[{"name":"Medical Services Australian Red Cross Blood Servic Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Warrilow","sequence":"additional","affiliation":[{"name":"Public Health Virology Laboratory, Forensic and Scientific Services Queensland Healt Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Northill","sequence":"additional","affiliation":[{"name":"Public Health Virology Laboratory, Forensic and Scientific Services Queensland Healt Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry A.","family":"Holmberg","sequence":"additional","affiliation":[{"name":"Grifols Diagnostic Solutions Inc. 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