{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:03:04Z","timestamp":1790611384946,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,9,25]],"date-time":"2016-09-25T00:00:00Z","timestamp":1474761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Changes in demographics with increases in older age groups and decreases in younger age groups imply an increased demand for blood transfusions paralleled by a decrease in the population eligible for blood donation. However, more restrictive transfusion triggers and the patient blood management initiative also reduce the demand for red blood cells (RBCs). Eastern Germany is a model region for the impact of demographic changes, which manifest in this region approximately 10 years earlier than in other regions due to the 50% birth rate decline after 1989.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>We report the 2010 longitudinal 5\u2010year follow\u2010up of the study assessing all whole blood donations and RBC transfusions in Mecklenburg\u2010West Pomerania. We compared the projections that were made 5\u00a0years ago with: 1) the current age structure of the blood donor and transfusion recipient populations and 2) its impact on blood demand and blood donation numbers in specific age groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Transfusion rates were lower and blood donation rates were higher than predicted in 2005. Although transfusion rates\/1000 decreased in nearly all age groups, the overall annual transfusion rate increased to 66.4 RBC units\/1000 (in 2005, 62.2\/1000) due to the absolute increase in the elderly population. Despite a 7.4% decline in the population 18 to 65 years of age, whole blood donations increased by 11.7% between 2005 and 2010, but thereafter decreased by 21% (first\u2010time donors by 39.4%), reflecting the effect of the post\u20101990 birth rate decline on the donor population.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Changes in demography and medical practice impact the delicate balance between available blood supply and potential future transfusion needs. In times of pronounced demographic changes, regular monitoring of the blood demand and age structure of blood recipients and donors is required to allow strategic planning to prevent blood shortages or overproduction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13814","type":"journal-article","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T04:07:00Z","timestamp":1474862820000},"page":"2986-2994","source":"Crossref","is-referenced-by-count":36,"title":["A population\u2010based longitudinal study on the implications of demographics on future blood supply"],"prefix":"10.1111","volume":"56","author":[{"given":"Andreas","family":"Greinacher","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Immunologie und Transfusionsmedizin Greifswald"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Weitmann","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Community Medicine, Universit\u00e4tsmedizin Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Lebsa","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Immunologie und Transfusionsmedizin Greifswald"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Alpen","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Immunologie und Transfusionsmedizin Greifswald"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Gloger","sequence":"additional","affiliation":[{"name":"Haema Blutspendezentrum Rostock Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Stangenberg","sequence":"additional","affiliation":[{"name":"Blutspendedienst Deutsches Rotes Kreuz Mecklenburg\u2010Vorpommern Neubrandenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Kiefel","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Transfusionsmedizin, Universit\u00e4tsmedizin Rostock Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Community Medicine, Universit\u00e4tsmedizin Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02882.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10389-007-0142-0"},{"key":"e_1_2_7_4_1","unstructured":"Aktualisierte 4. Landesprognose des Statistischen Amtes des Landes Mecklenburg\u2010Vorpommern Basisjahr 31.12.2010 (Variante 2) [Internet]. Wiesbaden: Federal Statistical Office;2010[cited 2016 Aug 26]. Available from:https:\/\/www.destatis.de\/GPStatistik\/servlets\/MCRFileNodeServlet\/MVHeft_derivate_00000245\/A1832_2012_01.pdf."},{"key":"e_1_2_7_5_1","unstructured":"Ergebnisse der 13. Koordinierten Bev\u00f6lkerungsvorausberechnung (Basis: 31.12.2013) (Statistisches Bundesamt) Kontinuit\u00e4t bei st\u00e4rkerer Zuwanderung (G1\u2010L1\u2010W2) [Internet]. Wiesbaden: Federal Statistical Office;2013[cited 2016 Aug 26]. Available from:https:\/\/www.demografie-portal.de\/SharedDocs\/Downloads\/DE\/BerichteKonzepte\/Bund\/Bevoelkerungsvorausberechnung_2015.pdf."},{"key":"e_1_2_7_6_1","unstructured":"United Nations Data Record [Internet]. New York: United Nations Statistics Data; c2016 [cited 2016 Jul 8]. Available from:http:\/\/data.un.org\/Data.aspx?d=POP&f=tableCode%3a22."},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2010.01446.x"},{"key":"e_1_2_7_8_1","volume-title":"Clinical guidelines blood transfusion","year":"2015"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61999-1"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv574"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02716.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01129.x"},{"key":"e_1_2_7_13_1","unstructured":"AhmadO Boschi\u2010PintoC LopezAD et al. Age standardization of rates: a new WHO standard. GPE Discussion Paper Series: No. 31. [Internet]. Geneva: World Health Organization;2001[cited 2016 Jul 8]. Available from:www.who.int\/healthinfo\/paper31.pdf."},{"key":"e_1_2_7_14_1","unstructured":"TivigT FroschK K\u00fchntopfS.Mapping regional demographic change and regional demographic location risk in Europe. Econsense \u2010 Forum Nachhaltige Entwicklung der Deutschen Wirtschaft e.V. Schriftenreihe zu Nachhaltigkeit und CSR. Berlin;2008:1\u2013108."}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.13814","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.13814","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.13814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:17:42Z","timestamp":1695539862000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.13814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,25]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1111\/trf.13814"],"URL":"https:\/\/doi.org\/10.1111\/trf.13814","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,25]]}}}