{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:06:46Z","timestamp":1773234406963,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T00:00:00Z","timestamp":1473379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Myasthenia gravis (MG) is a neuromuscular disorder characterized by an autoimmune defect in the neuromuscular junction. In most patients, the autoimmune attack is mediated by antibodies against the acetylcholine receptor (AChR) on the postsynaptic membrane. Deficient immunoregulation, including regulatory T cells, is consistently observed. Extracorporeal photopheresis (ECP) leads to the induction of regulatory T cells that mediate immunologic tolerance in autoimmune diseases; however, the data regarding MG are very limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>CASE REPORT<\/jats:title><jats:p>Here, we report a patient who, during ongoing ECP therapy for his severe, refractory, chronic graft\u2010versus\u2010host disease (cGVHD), developed MG, although he responded very well to ECP, as indicated by the lowering of his chronic cGVHD severity grade to moderate.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Despite receiving ECP, our patient developed MG, which was resistant to treatment and required intensive care unit support.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Close surveillance is required when ECP is planned as one of the treatment alternatives in myasthenia gravis that develop in cGVHD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13821","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T20:22:53Z","timestamp":1473452573000},"page":"3081-3085","source":"Crossref","is-referenced-by-count":4,"title":["Extracorporeal photopheresis did not prevent the development of an autoimmune disease: myasthenia gravis"],"prefix":"10.1111","volume":"56","author":[{"given":"Vedat","family":"Uygun","sequence":"first","affiliation":[{"name":"Pediatric Bone Marrow Transplantation Unit Medical Park Antalya Hospital, Bah\u00e7e\u015fehir University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayriye","family":"Dalo\u011flu","sequence":"additional","affiliation":[{"name":"Pediatric Bone Marrow Transplantation Unit Medical Park Antalya Hospital Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seda Irmak","family":"\u00d6zt\u00fcrkmen","sequence":"additional","affiliation":[{"name":"Pediatric Bone Marrow Transplantation Unit Medical Park Antalya Hospital Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levent","family":"D\u00f6\u015femeci","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Istanbul Kemerburgaz University Faculty of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcls\u00fcn","family":"Karasu","sequence":"additional","affiliation":[{"name":"Pediatric Bone Marrow Transplantation Unit, Medical Park G\u00f6ztepe Hospital Bah\u00e7e\u015fehir University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volkan","family":"Hazar","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology and Bone Marrow Transplantation Unit Medipol University Faculty of Medicine Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akif","family":"Ye\u015filipek","sequence":"additional","affiliation":[{"name":"Pediatric Bone Marrow Transplantation Unit Medical Park Antalya Hospital, Bah\u00e7e\u015fehir University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12217"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e328364c079"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2012.06791.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-11-125542"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21367"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12311"},{"key":"e_1_2_6_8_1","first-page":"11","article-title":"Photopheresis\u2014a new method for treatment of myasthenia","volume":"103","author":"Neretin V","year":"2003","journal-title":"Zh Nevrol Psikhiatr Im S S 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