{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T11:46:18Z","timestamp":1789818378952,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T00:00:00Z","timestamp":1477440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Acute hepatitis E in industrialized countries is usually related to intake or manipulation of undercooked or raw meat. Cases of transfusion\u2010transmitted hepatitis E have rarely been documented in immunosuppressed patients, mainly after receiving frozen plasma.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>A 61\u2010year\u2010old man was admitted to hospital for jaundice. His personal history included disseminated bacillus Calmette\u2010Guerin infection treated with antituberculous drugs. He had received red blood cell (RBC) transfusion 2 months previously, during admission for mycotic aneurysm surgery. Since liver function tests worsened despite stopping antituberculous drugs, other causes of acute hepatitis were explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Acute hepatitis E was diagnosed by the presence of both immunoglobulin M and hepatitis E virus (HEV) RNA. Traceback procedure for the 8 RBC units was carried out, and one of the eight archive plasma samples tested positive for HEV RNA, with an estimated viral load of 75,000 IU\/mL. Phylogenetic analysis revealed the same HEV strain Genotype 3 in one of the transfused RBC products and in the patient's serum sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Transfusion of RBCs with detectable HEV RNA is a risk factor for acute hepatitis E in immunocompetent patients in Europe.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13876","type":"journal-article","created":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T03:17:14Z","timestamp":1477538234000},"page":"244-247","source":"Crossref","is-referenced-by-count":44,"title":["Red blood cell transfusion\u2010transmitted acute hepatitis E in an immunocompetent subject in Europe: a case report"],"prefix":"10.1111","volume":"57","author":[{"given":"Mar","family":"Riveiro\u2010Barciela","sequence":"first","affiliation":[{"name":"Liver Unit, Department of Internal Medicine Hospital Universitari Vall d'Hebron and Universitat Aut\u00f2noma de Barcelona Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Sauleda","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III Madrid Spain"},{"name":"Transfusion Safety Laboratory Banc de Sang i Teixits, Servei Catal\u00e0 de la Salut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Quer","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III Madrid Spain"},{"name":"Liver Unit, Internal Medicine Lab. Malalties Hep\u00e0tiques, Vall d'Hebron Institut Recerca\u2010Hospital Universitari Vall d'Hebron (VHIR\u2010HUVH)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Salvador","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Hospital Universitari Vall d'Hebron, Universitat Aut\u00f2noma de Barcelona, PROSICS Barcelona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Gregori","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III Madrid Spain"},{"name":"Liver Unit, Internal Medicine Lab. 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