{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T04:23:08Z","timestamp":1768969388044,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,12,4]],"date-time":"2016-12-04T00:00:00Z","timestamp":1480809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Acquired Factor (F)XIII deficiency is a very rare bleeding diathesis with a potentially fatal outcome, previously described in the context of autoimmune disorders and leukemias. There is minimal information on autoantibody characterization and the role of antifibrinolytic therapy in patient management.<\/jats:p><\/jats:sec><jats:sec><jats:title>CASE REPORT<\/jats:title><jats:p>A 79\u2010year\u2010old woman with a 3\u2010month history of bruising and heavy menorrhagia presented with ongoing vaginal bleeding, symptomatic anemia, and a right thigh hematoma. Initial management included an axillary lymph node biopsy and coagulation evaluation. Pathologic examination of the biopsy specimen revealed mantle cell lymphoma. Clot solubility assay was consistent with a FXIII activity of\u00a0less than 3%. An anti\u2010FXIII inhibitor was suspected, the epitope specificity of which was mapped by micropeptide array analysis to regions in the \u03b2\u2010sandwich and catalytic core domain of the FXIII\u2010A subunit. Management with cryoprecipitate, steroids, rituximab, and antifibrinolytic therapy resolved the bleeding diathesis and suppressed the inhibitor.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>This is the first reported case of an acquired FXIII inhibitor associated with mantle cell lymphoma in which the epitope specificity of the pathologic autoantibody was accurately defined. Antifibrinolytic therapy played a prominent role in the prevention of bleeding complications in the window period between initiation of immunosuppression and disappearance of the pathologic anti\u2010FXIII autoantibody.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13947","type":"journal-article","created":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T03:10:39Z","timestamp":1480907439000},"page":"694-699","source":"Crossref","is-referenced-by-count":10,"title":["Acquired Factor XIII inhibitor associated with mantle cell lymphoma"],"prefix":"10.1111","volume":"57","author":[{"given":"Christian P.","family":"Nixon","sequence":"first","affiliation":[{"name":"Center for International Health Research, Rhode Island Hospital and Alpert Medical School of Brown University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth H.","family":"Prsic","sequence":"additional","affiliation":[{"name":"Department of Hematology &amp; Oncology Rhode Island Hospital and The Miriam Hospitals"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine A.","family":"Guertin","sequence":"additional","affiliation":[{"name":"Department of Coagulation Rhode Island Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan L.","family":"Stevenson","sequence":"additional","affiliation":[{"name":"Department of Hematology &amp; Oncology Rhode Island Hospital and The Miriam Hospitals"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph D.","family":"Sweeney","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Rhode Island Hospital and The Miriam Hospitals, Alpert Medical School of Brown University Providence Rhode Island"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)66755-9"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M002901200"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.04070.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(93)22005-Z"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH07-01-0034"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH12-08-0604"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-012-0818-3"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/10245332.2015.1101975"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02830.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1974.tb00222.x"},{"key":"e_1_2_5_12_1","first-page":"137","article-title":"The detection and measurement of factor XIII activity: a review","volume":"37","author":"Francis J.","year":"1980","journal-title":"Med Lab Sci"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04315.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1225765"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.02021.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02459.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1974.tb00472.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku340"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bti770"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn750"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200900140"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)00098-2"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.15.7296"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.8.4917"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.35.24953"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-09-179333"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12877"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-999040"},{"key":"e_1_2_5_29_1","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1182\/blood.V63.6.1393.1393","article-title":"Differential binding of plasminogen to crosslinked and noncrosslinked fibrins: its significance in hemostatic defect in factor XIII deficiency","volume":"63","author":"Sakata Y","year":"1984","journal-title":"Blood"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.13947","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.13947","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T13:17:24Z","timestamp":1695475044000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.13947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,4]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/trf.13947"],"URL":"https:\/\/doi.org\/10.1111\/trf.13947","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,4]]}}}