{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:16:08Z","timestamp":1793394968440,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T00:00:00Z","timestamp":1485820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>The incidence of hepatitis E virus (HEV) has increased substantially in Europe recently, thereby threatening blood safety. A cost\u2010effectiveness analysis for HEV screening of blood donations in the Netherlands was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY DESIGN AND METHODS<\/jats:title>\n                    <jats:p>A simulation model was developed to mimic the process of donation, infections in the donor population, donation testing, and transmission to transfusion recipients. The variability of viral loads among donors was modeled using observed loads. The number of (incurable) chronic HEV infections among organ and stem cell transplant patients and the costs avoided by implementing blood screening were estimated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>HEV screening of whole blood donations in pools of 24 would prevent 4.52 of the 4.94 transfusion\u2010associated chronic HEV infections expected annually, at approximately \u20ac310,000 per prevented chronic case. Per case not curable by ribavirin prevention, costs are approximately 10 times higher. Selective screening, if logistically feasible, could reduce screening costs by 85%. Sensitivity analyses show that uncertainty in the HEV transmissibility and the frequency of HEV clearing greatly impact the estimated cost\u2010effectiveness. Of all HEV infections nationwide one in 700 is estimated to be due to blood transfusion, while for chronic infections this is one in 3.5.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Despite uncertainties in our estimates, preventing HEV transmission by screening of blood donations appears not excessively expensive compared to other blood\u2010screening measures in the Netherlands. However, the impact on HEV disease burden may be relatively small as only a minority of all HEV cases is transmitted by blood transfusion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/trf.13978","type":"journal-article","created":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T23:56:33Z","timestamp":1485906993000},"page":"258-266","source":"Crossref","is-referenced-by-count":50,"title":["Cost\u2010effectiveness of the screening of blood donations for hepatitis E virus in the Netherlands"],"prefix":"10.1111","volume":"57","author":[{"given":"Anneke S.","family":"de Vos","sequence":"first","affiliation":[{"name":"Transfusion Technology Assessment Unit Sanquin Research Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart P.","family":"Janssen","sequence":"additional","affiliation":[{"name":"Transfusion Technology Assessment Unit Sanquin Research Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans L.","family":"Zaaijer","sequence":"additional","affiliation":[{"name":"Department of Blood\u2010Borne Infections Sanquin Research Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris M.","family":"Hogema","sequence":"additional","affiliation":[{"name":"Department of Blood\u2010Borne Infections Sanquin Research Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61034-5"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES2013.18.31.20550"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit652"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.02.014"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2006.00652.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1304.061387"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01722.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2011.140516"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215246"},{"key":"e_1_2_7_11_1","volume-title":"R: a language and environment for statistical computing","author":"R Core Team","year":"2015"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13402"},{"key":"e_1_2_7_13_1","volume-title":"Kengetallen bloedvoorziening, infectiecijfers en ongebruikte volledige donaties [Internet]","year":"2016"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.02.050"},{"key":"e_1_2_7_15_1","unstructured":"Data recalculated from 1 shown by Richard Tedder at the IPFA conference in Prague May2015."},{"key":"e_1_2_7_16_1","volume-title":"Blood\u2010transfusion Guideline [Internet]","year":"2011"},{"key":"e_1_2_7_17_1","volume-title":"Information for users of blood products guideline [Internet]","year":"2015"},{"key":"e_1_2_7_18_1","volume-title":"Summary of product characteristics (SPC) Omniplasma [Internet]","author":"Sanquin Plasma Products","year":"2016"},{"key":"e_1_2_7_19_1","volume-title":"Cijfers over donatie en transplantatie [Internet]","year":"2016"},{"key":"e_1_2_7_20_1","volume-title":"Annual report 2014 [Internet]","year":"2015"},{"key":"e_1_2_7_21_1","volume-title":"Hepatitis E virus transfusion and transplantation risk reduction working group report [Internet]","author":"Advisory Committee on the Safety of Blood","year":"2015"},{"key":"e_1_2_7_22_1","volume-title":">Medication costs [Internet]","year":"2016"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163488"},{"key":"e_1_2_7_24_1","volume-title":"Disease reports hepatitis C, included with the ECDC BCoDE toolkit software application [Internet]. 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