{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T19:04:59Z","timestamp":1761419099060},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T00:00:00Z","timestamp":1487030400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21H2121740"],"award-info":[{"award-number":["R21H2121740"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Transfusion transmission of hepatitis E virus (HEV) is an emerging health risk, yet blood donors are rarely screened for this pathogen. Many blood centers instituted screening of blood donors for elevated levels of alanine aminotransferase (ALT) levels to prevent hepatitis\u00a0C virus, which has continued in China. We evaluated whether elevated ALT levels were associated with HEV among blood donors in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>Blood samples were collected from 9069 qualified volunteer blood donors from four blood centers in China. A total of 5023 had elevated ALT levels, that is,\u00a0more than 40\u00a0IU\/L, and 4046 samples had normal ALT. We tested all the 9069 samples for anti\u2010HEV immunoglobulin (Ig)M, anti\u2010HEV IgG, and HEV antigen. Those who were positive for anti\u2010HEV IgM or HEV antigen were tested individually for HEV RNA by polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The prevalence of anti\u2010HEV IgG in donors with elevated ALT levels (33.3%) was higher than those with normal ALT (24.9%; p\u00a0&lt;\u00a00.01). The prevalence of anti\u2010HEV IgM was similar in donations with increased ALT (1.41%) and normal ALT (1.46%). More ALT\u2010elevated donations were HEV antigen positive, 62 of 5023 (1.23%), than were ALT\u2010normal donations, seven of 4046 (0.17%; p\u00a0&lt;\u00a00.01). Six donors with elevated ALT levels and acute HEV infection markers (anti\u2010HEV IgM or HEV antigen) were HEV RNA positive.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Markers of active infection including HEV antigen and HEV RNA are significantly more common among donors with elevated ALT levels in China. These data support the fact that ALT testing of donors to HEV antigen or HEV RNA would have greater specificity and exclude fewer acceptable donors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.13991","type":"journal-article","created":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T06:10:43Z","timestamp":1487052643000},"page":"273-279","source":"Crossref","is-referenced-by-count":14,"title":["The association of elevated alanine aminotransferase levels with hepatitis E virus infections among blood donors in China"],"prefix":"10.1111","volume":"57","author":[{"given":"Meiyu","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Blood Transfusion, Chinese Academy of Medical Sciences Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion, Chinese Academy of Medical Sciences Chengdu 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