{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T21:12:13Z","timestamp":1724965933064},"reference-count":23,"publisher":"Wiley","issue":"3pt2","license":[{"start":{"date-parts":[[2017,2,5]],"date-time":"2017-02-05T00:00:00Z","timestamp":1486252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Canadian Blood Services, Small Project Fund"},{"name":"Canadian Institute of Health Research\/Canadian Blood Services New Investigator Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Exposure to blood products during pregnancy carries a potential risk of transfusion transmission of infectious agents. Blood agencies have historically sought optimal deferral and testing strategies to protect blood supplies in part to ensure the protection of pregnant women and their unborn infants. The Zika virus outbreak of 2016 has heightened attention to these concerns. In the current context of the recent Zika outbreak, and also more broadly, data are needed to shed light on the likelihood of exposure to blood products throughout pregnancy to inform policy.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>Hospital administrative data from a large tertiary care center were examined for outpatient and nondelivery inpatient transfusion events in pregnant women between January 1, 2007, and December 31, 2013. Those pregnancies resulting in miscarriage were excluded from analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 45,179 pregnancies resulting in delivery of a live or stillborn infant were documented at The Ottawa Hospital during the study period. Our findings indicate that 0.124%, or 1240 in 1,000,000, expectant mothers received transfusion at some point during their pregnancies with 0.04%, or 400 per 1,000,000, expectant mothers receiving a transfusion in the first trimester.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Data from a large tertiary care center suggest that the risk of maternal and fetal exposure to blood products by transfusion during any stage of pregnancy is very low. Such a low likelihood of transfusion should be taken into consideration when developing donor deferral policies designed to protect women against transfusion\u2010associated infection transmission during pregnancy and could inform evaluations of the risk of prenatal transfusion transmission of the Zika virus.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.14001","type":"journal-article","created":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T03:17:12Z","timestamp":1486351032000},"page":"811-815","source":"Crossref","is-referenced-by-count":8,"title":["Risk of exposure to blood products during pregnancy: guidance for Zika and other donor deferral policies"],"prefix":"10.1111","volume":"57","author":[{"given":"Malia S.Q.","family":"Murphy","sequence":"first","affiliation":[{"name":"Clinical Epidemiology Program Ottawa Hospital Research Institute Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Shehata","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Laboratory Medicine and Pathobiology Institute of Health Policy Management and Evaluation, University of Toronto, Division of Hematology, Mount Sinai Hospital Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo Ann","family":"Colas","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Program Ottawa Hospital Research Institute Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha\u00ebl","family":"Chass\u00e9","sequence":"additional","affiliation":[{"name":"Department of Medicine Universit\u00e9 de Montr\u00e9al"},{"name":"Centre de Recherche du Centre Hospitalier Universitaire de Montr\u00e9al Montr\u00e9al Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean A.","family":"Fergusson","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Program Ottawa Hospital Research Institute Ottawa Ontario Canada"},{"name":"Department of Medicine University of Ottawa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila F.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Canadian Blood Services Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mindy","family":"Goldman","sequence":"additional","affiliation":[{"name":"Canadian Blood Services Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Tinmouth","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Program Ottawa Hospital Research Institute Ottawa Ontario Canada"},{"name":"Department of Medicine University of Ottawa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan J.","family":"Forster","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Program Ottawa Hospital Research Institute Ottawa Ontario Canada"},{"name":"Department of Medicine University of Ottawa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumanan","family":"Wilson","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Program Ottawa Hospital Research Institute Ottawa Ontario Canada"},{"name":"Department of Medicine University of Ottawa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S89308"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.5501\/wjv.v4.i2.113"},{"key":"e_1_2_7_4_1","unstructured":"Prevent dengue during pregnancy [Internet]. Atlanta (GA): Centers for Disease Control and Prevention; [cited 2016 Nov 03]. Available from:http:\/\/www.cdc.gov\/dengue\/resources\/educationmaterials_pdfs\/15_261427-a_seda_508_update_prevent_dengue_during_pregnancy508.pdf."},{"key":"e_1_2_7_5_1","unstructured":"New blood donation rules protect Canadian blood supply from Zika virus [press release]. Ottawa: Canadian Blood Services;2016Feb 3."},{"key":"e_1_2_7_6_1","unstructured":"Revised recommendations for reducing the risk of Zika virus transmission by blood and blood components: guidance for industry [Internet]. Silver Spring (MD): U.S. Food and Drug Administration U.S. Department of Health and Human Services;2016[cited 2016 Nov 27]. Available from:http:\/\/www.fda.gov\/downloads\/BiologicsBloodVaccines\/GuidanceComplianceRegulatoryInformation\/Guidances\/Blood\/UCM518213.pdf."},{"key":"e_1_2_7_7_1","unstructured":"WHO statement on the first meeting of the International Health Regulations(2005) (IHR 2005) Emergency Committee on Zika Virus and Observed Increase in Neurological Disorders and Neonatal Malformations [press release]. Geneva: World Health Organization;2016Feb 1."},{"key":"e_1_2_7_8_1","unstructured":"Zika situation report. Zika virus microcephaly Guillain\u2010Barr\u00e9 syndrome. [Internet]. Geneva: World Health Organization;2016[cited 2016 Aug 25]. Available from:http:\/\/www.who.int\/emergencies\/zika-virus\/situation-report\/29-december-2016\/en\/."},{"key":"e_1_2_7_9_1","unstructured":"Possible association between Zika virus infection and microcephaly\u2014Brazil 2015 [Internet]. Atlanta (GA): Centers for Disease Control and Prevention;2016[cited 2016 Aug 25]. Available from:http:\/\/www.cdc.gov\/mmwr\/volumes\/65\/wr\/mm6503e2.htm."},{"key":"e_1_2_7_10_1","unstructured":"Zika virus infection: Global Update [Internet]. Government of Canada; 2016 [cited 2017 Jan 03]. 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