{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:28:25Z","timestamp":1781512105171,"version":"3.54.1"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T00:00:00Z","timestamp":1490918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Paroxysmal cold hemoglobinuria (PCH) is a form of autoimmune hemolytic anemia caused by the Donath\u2010Landsteiner antibody (D\u2010L antibody). In children, this is typically a transient immune\u2010mediated hemolysis that follows a viral illness and does not recur. Recurrent acute or chronic PCH due to D\u2010L antibody is very rare.<\/jats:p><\/jats:sec><jats:sec><jats:title>CASE REPORT<\/jats:title><jats:p>We have reported a unique case of recurrent PCH in a 5\u2010year\u2010old boy with two acute episodes of hemolysis separated by 21 months of hematologic remission. Each episode was severe requiring red blood cell transfusions, intravenous methylprednisolone, and intravenous immunoglobulin during the second episode. Testing identified recurrence of the D\u2010L antibody with the classic anti\u2010P biphasic hemolysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>This demonstrates that PCH can be a recurrent disease in the pediatric population (in the absence of syphilis) with the classical D\u2010L antibody.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.14032","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T07:22:30Z","timestamp":1490944950000},"page":"1401-1406","source":"Crossref","is-referenced-by-count":21,"title":["Recurrent Donath\u2010Landsteiner hemolytic anemia: a pediatric case report"],"prefix":"10.1111","volume":"57","author":[{"given":"Sara D.","family":"Prince","sequence":"first","affiliation":[{"name":"Nemours Alfred I. DuPont Hospital for Children Wilmington Delaware"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena E.","family":"Winestone","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology Children's Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra J.","family":"Nance","sequence":"additional","affiliation":[{"name":"Immunohematology Reference Laboratories American Red Cross Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology Children's Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1309\/LM1E9Z2QZEREPAI"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2007.08.002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(74)90751-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24185"},{"key":"e_1_2_7_6_1","volume-title":"Immunohematology methods","author":"Mallory D.","year":"1993"},{"key":"e_1_2_7_7_1","volume-title":"Practical haematology","author":"Dacie JV","year":"1968"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3148.2003.00460.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0958-7578.2004.00521.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e31814d6845"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-7963(89)70082-1"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200204000-00039"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000476"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.399"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-01-196329"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.14032","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.14032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T19:55:26Z","timestamp":1695498926000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.14032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,31]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/trf.14032"],"URL":"https:\/\/doi.org\/10.1111\/trf.14032","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,31]]}}}