{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:32:11Z","timestamp":1790040731332,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","issue":"3pt2","license":[{"start":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T00:00:00Z","timestamp":1487808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Zika virus (ZIKV) is transmitted by <jats:italic>Aedes<\/jats:italic> mosquitos and can result in severe congenital and adult neurologic abnormalities. ZIKV has rapidly spread northward through Central America and the Caribbean and autochthonous cases have been identified in the continental United States. High rates of ZIKA RNA positivity were detected in blood donors during previous epidemics. ZIKV transmission by transfused blood from healthy donor components has been a growing concern.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>Individual\u2010donation aliquots of plasma from volunteer blood donors were tested individually with an investigational Procleix ZIKV assay. Initially reactive samples were tested for ZIKV RNA in plasma and red blood cells (RBCs) and for ZIKV\u2010specific antibodies in serum. A confirmed positive classification required confirmation of RNA and\/or detection of ZIKV antibodies in index and\/or follow\u2010up samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Between September 19 and November 30, 2016, a total of 466,834 donations were screened for ZIKV RNA. Five donors (one in approx. 93,000) were reactive for ZIKV RNA by both the Procleix ZIKV assay and supplemental testing. The donations were collected outside areas considered as having active transmission, and all five donors had travel exposures. A lookback case demonstrated no infection despite transfusion of a Zika IgG\u2013positive platelet (PLT) component with probable low levels of ZIKV RNA.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>This report describes the first ZIKV\u2010positive donors detected outside areas with active transmission. These donors most likely represent travel\u2010acquired \u201ctail\u2010end infections\u201d with prolonged RBC\u2010associated ZIKV RNA. The lack of transmission to the recipient of an apheresis PLT may suggest that these units are not infectious.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.14041","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T07:43:29Z","timestamp":1487835809000},"page":"770-778","source":"Crossref","is-referenced-by-count":61,"title":["First cases of Zika virus\u2013infected US blood donors outside states with areas of active transmission"],"prefix":"10.1111","volume":"57","author":[{"given":"Phillip C.","family":"Williamson","sequence":"first","affiliation":[{"name":"Creative Testing Solutions Tempe Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Linnen","sequence":"additional","affiliation":[{"name":"Hologic, Inc San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra A.","family":"Kessler","sequence":"additional","affiliation":[{"name":"New York Blood Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth H.","family":"Shaz","sequence":"additional","affiliation":[{"name":"New York Blood Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany","family":"Kamel","sequence":"additional","affiliation":[{"name":"Blood Systems, Inc Scottsdale Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph R.","family":"Vassallo","sequence":"additional","affiliation":[{"name":"Blood Systems, Inc Scottsdale Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Winkelman","sequence":"additional","affiliation":[{"name":"Creative Testing Solutions Tempe Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Gao","sequence":"additional","affiliation":[{"name":"Hologic, Inc San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Ziermann","sequence":"additional","affiliation":[{"name":"Hologic, Inc San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juscilene","family":"Menezes","sequence":"additional","affiliation":[{"name":"Hologic, Inc San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Thomas","sequence":"additional","affiliation":[{"name":"Hologic, Inc San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry A.","family":"Holmberg","sequence":"additional","affiliation":[{"name":"Grifols Diagnostic Solutions, Inc Emeryville California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Bakkour","sequence":"additional","affiliation":[{"name":"Blood Systems Research Institute San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mars","family":"Stone","sequence":"additional","affiliation":[{"name":"Blood Systems Research Institute San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Lu","sequence":"additional","affiliation":[{"name":"Blood Systems Research Institute San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Simmons","sequence":"additional","affiliation":[{"name":"Blood Systems Research Institute San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Busch","sequence":"additional","affiliation":[{"name":"Blood Systems Research Institute San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/0074-02760160332"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004517"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15831"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES2014.19.13.20751"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1705.101939"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2102.141363"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13681"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1607262"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES2014.19.14.20761"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2006.140138"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2011.141253"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12707"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2110.151125"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2015.10.004"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6506e2"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6538e1"},{"key":"e_1_2_8_18_1","volume-title":"Texas announces local Zika virus case in Rio Grande Valley","year":"2016"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(64)90201-9"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(56)90090-6"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(52)90043-6"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2015.12.003"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.7326\/M16-0332"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00320-2"},{"key":"e_1_2_8_25_1","first-page":"294","article-title":"Zika virus","volume":"375","author":"Petersen LR","year":"2016","journal-title":"N Engl J Med"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1604338"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.19006"},{"key":"e_1_2_8_28_1","first-page":"95","article-title":"Zika virus and the never\u2010ending story of emerging pathogens and transfusion medicine","volume":"14","author":"Marano G","year":"2016","journal-title":"Blood Transfus"},{"key":"e_1_2_8_29_1","first-page":"93","article-title":"Blood safety and zoonotic emerging pathogens: now it's the turn of Zika virus!","volume":"14","author":"Franchini M","year":"2016","journal-title":"Blood Transfus"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2014.12.005"},{"key":"e_1_2_8_31_1","volume-title":"Recommendations for donor screening, deferral, and product management to reduce the risk of transfusion\u2010transmission of Zika virus: guidance for industry","author":"Food and Drug Administration","year":"2016"},{"key":"e_1_2_8_32_1","volume-title":"Revised recommendations for reducing the risk of Zika virus transmission by blood and blood components: guidance for Industry","author":"Food and Drug Administration","year":"2016"},{"key":"e_1_2_8_33_1","volume-title":"Updated recommendations for Zika, dengue, and chikungunya viruses","year":"2016"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6524e2"},{"key":"e_1_2_8_35_1","unstructured":"Trioplex real\u2010time RT\u2010PCR assay [Internet]. Atlanta: Centers for Disease Control and Prevention;2016[cited 2016 Dec 19]. Available from:http:\/\/www.fda.gov\/downloads\/MedicalDevices\/Safety\/EmergencySituations\/UCM491592.pdf. last accessed on December 19 16."},{"key":"e_1_2_8_36_1","unstructured":"BakkourS LeeT StoneM et al. Analytical performance of PCR assays for detection of Zika virus RNA. Orlando (FL): American Association of Blood Banks Annual Meeting;2016."},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14031"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14026"},{"key":"e_1_2_8_39_1","unstructured":"Zika MAC\u2010ELISA [Internet]. Atlanta:Centers for Disease Control and Prevention;2016[cited 2016 Dec 19]. Available from:http:\/\/www.fda.gov\/downloads\/MedicalDevices\/Safety\/EmergencySituations\/UCM488044.pdf. last accessed on December 19 16."},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1408.080287"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw122"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027252"},{"key":"e_1_2_8_43_1","unstructured":"BresV SelfD OcampoD et al. Performance characteristics of a transcription\u2010mediated amplification assay on a fully automated system to detect Babesia in blood donations. Orlando (FL): American Association of Blood Banks Annual Meeting;2016."},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2301.161394"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2016.21.26.30269"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12764"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.14041","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.14041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T17:35:35Z","timestamp":1694626535000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.14041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,23]]},"references-count":45,"journal-issue":{"issue":"3pt2","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/trf.14041"],"URL":"https:\/\/doi.org\/10.1111\/trf.14041","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,23]]}}}