{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:08:47Z","timestamp":1763017727669,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T00:00:00Z","timestamp":1489104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Swiss National Foundation","award":["32473B_125482\/1"],"award-info":[{"award-number":["32473B_125482\/1"]}]},{"name":"Nora van Meeuwen-H\u00e4fliger Foundation"},{"name":"Blood Transfusion Service, Swiss Red Cross"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Alloimmunization against human platelet antigens (HPAs) during pregnancy is rare but can lead to severe bleeding disorders, such as fetal and neonatal alloimmune thrombocytopenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>In a cohort of 241 uncomplicated pregnancies, we investigated the immunogenicity of HPA mismatches and correlated HLA sensitization with HPA antibody formation. HPA antibodies were measured with a Luminex\u2010based multiplex assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>HPA mismatches were observed in 109 of 241 pregnancies (45%), but child\u2010specific HPA antibodies were only found in two of 109 cases (2%), indicating a low immunogenicity. Only nine of 241 women (4%) had detectable HPA antibodies. HLA sensitization was identified as a strong and independent predictor for HPA antibody formation (hazard ratio, 10.2; 95% confidence interval, 1.8\u2010193; p\u2009=\u20090.006), whereas the number of pregnancies was not.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Our observational data indicated a low immunogenicity of HPA and suggest that a broader immune response\u2014inferred by HLA sensitization\u2014is probably associated with HPA antibody induction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.14053","type":"journal-article","created":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T17:31:45Z","timestamp":1489167105000},"page":"1272-1279","source":"Crossref","is-referenced-by-count":5,"title":["Human platelet antigen antibody induction in uncomplicated pregnancy is associated with HLA sensitization"],"prefix":"10.1111","volume":"57","author":[{"given":"Viktoria S.A.","family":"Reiher","sequence":"first","affiliation":[{"name":"Regional Blood Transfusion Service Swiss Red Cross"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gideon","family":"H\u00f6nger","sequence":"additional","affiliation":[{"name":"Transplantation Immunology and Nephrology, University Hospital Basel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Infanti","sequence":"additional","affiliation":[{"name":"Regional Blood Transfusion Service Swiss Red Cross"},{"name":"Division of Hematology University Hospital Basel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob R.","family":"Passweg","sequence":"additional","affiliation":[{"name":"Division of Hematology University Hospital Basel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"H\u00f6sli","sequence":"additional","affiliation":[{"name":"Department for Obstetrics and Fetomaternal Medicine University Hospital Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beat 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