{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:48:50Z","timestamp":1790419730763,"version":"4.1.0"},"reference-count":3,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T00:00:00Z","timestamp":1488844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Rd (SC4) is a low\u2010frequency antigen of the Scianna blood group system. Only very few reports on anti\u2010Rd in pregnancy exist. Mild to moderate hemolytic disease of the newborn caused by anti\u2010Rd has been reported. This report may add further information on the clinical significance of anti\u2010Rd for the fetus.<\/jats:p><\/jats:sec><jats:sec><jats:title>CASE REPORT<\/jats:title><jats:p>In a case of severe fetal anemia (hemoglobin concentration, 3.0 g\/dL) repeated intrauterine transfusions were required. The strongly positive direct antiglobulin test (DAT) of the fetal red blood cells led to the diagnosis of hemolytic disease. The routine antibody screen was negative, extended testing revealed a maternal anti\u2010Rd with a titer of 256. Both the newborn and her father were confirmed to carry the <jats:italic>SC*01.04<\/jats:italic> allele.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Anti\u2010Rd can cause fetal anemia. Low\u2010frequency antigens including Rd are normally not present on screening cells. Antibodies directed against low\u2010frequency antigens will usually not be detected by routine antibody screening in pregnancy. Thus, in cases of fetal anemia the DAT should always be included in the diagnostic workup.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.14078","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T13:46:46Z","timestamp":1488894406000},"page":"1485-1487","source":"Crossref","is-referenced-by-count":4,"title":["A case of anti\u2010Rd causing fetal anemia"],"prefix":"10.1111","volume":"57","author":[{"given":"Stefan","family":"Rauch","sequence":"first","affiliation":[{"name":"Labor Prof. G. Enders &amp; Kollegen MVZ GbR Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Ritgen","sequence":"additional","affiliation":[{"name":"Praenatal.de K\u00f6ln, Prenatal Medicine and Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Wi\u00dfkirchen","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kinder\u2010 und Jugendmedizin, Kliniken der Stadt K\u00f6ln gGmbH and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Bauerfeind","sequence":"additional","affiliation":[{"name":"Institute of Transfusion Medicine, Blood Service, Cologne\u2010Merheim Medical Center Cologne, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Kohne","sequence":"additional","affiliation":[{"name":"Hemoglobin Laboratory, Department of Pediatrics University Hospital Ulm"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof","family":"Weinstock","sequence":"additional","affiliation":[{"name":"Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Service Baden\u2010W\u00fcrttemberg\u2013Hessen University of Ulm Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-2064"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.1967.tb04864.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.21307\/immunohematology-2019-173","article-title":"Scianna: the lucky 13th blood group system","volume":"27","author":"Brunker PA","year":"2011","journal-title":"Immunohematology"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.14078","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.14078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T19:55:20Z","timestamp":1695498920000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.14078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,7]]},"references-count":3,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/trf.14078"],"URL":"https:\/\/doi.org\/10.1111\/trf.14078","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,7]]}}}