{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T15:29:24Z","timestamp":1781191764648,"version":"3.54.1"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T00:00:00Z","timestamp":1490659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Passenger lymphocyte syndrome (PLS), a subtype of graft\u2010versus\u2010host disease, is a rare disorder encountered mainly in ABO\u2010mismatched hematopoietic stem cell transplantation and infrequently in all types of ABO\u2010mismatched solid organ transplantation. We here report the fifth case of PLS in small bowel transplantation (SBTx) and the first one describing the successful management of PLS in a cadaveric, isolated SBTx.<\/jats:p><\/jats:sec><jats:sec><jats:title>CASE REPORT<\/jats:title><jats:p>A 60\u2010year\u2010old Caucasian female with blood group A D+ suffering from short bowel syndrome received a small bowel transplant from a 32\u2010year\u2010old Caucasian female with blood group O D+ (HLA mismatch 2\/6). After onset of massive hemolysis on Postoperative Day 9 the positive direct and indirect antiglobulin tests showing antibodies against A1 and A2 red blood cells (RBCs) led to the diagnosis of PLS. This complication was successfully treated by transfusion of blood group O RBC transfusions, increased immunosuppression, and plasmapheresis.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>In the event of severe hemolysis and anemia after ABO\u2010mismatched SBTx, PLS should be considered. In our case successful treatment consisted of transfusion of donor\u2010specific RBCs, increased immunosuppression, and plasmapheresis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.14086","type":"journal-article","created":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T03:23:13Z","timestamp":1490757793000},"page":"1396-1400","source":"Crossref","is-referenced-by-count":18,"title":["Successful management of passenger lymphocyte syndrome in an ABO\u2010compatible, nonidentical isolated bowel transplant: a case report and review of the literature"],"prefix":"10.1111","volume":"57","author":[{"given":"Daniel","family":"Foell","sequence":"first","affiliation":[{"name":"Department of General and Visceral Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Glasmeyer","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine and Transplantation Immunology University Hospital of Muenster Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Senninger","sequence":"additional","affiliation":[{"name":"Department of General and Visceral Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiner","family":"Wolters","sequence":"additional","affiliation":[{"name":"Department of General and Visceral Surgery St\u2010Josefs\u2010Hospital Dortmund Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Palmes","sequence":"additional","affiliation":[{"name":"Department of General and Visceral Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Bahde","sequence":"additional","affiliation":[{"name":"Department of General and Visceral Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/715769"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1991.31191096190.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2004.00158.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2010.01045.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198612000-00008"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199606270-00022"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12582"},{"key":"e_1_2_6_9_1","first-page":"167","article-title":"Eluate testing following microscopically positive direct antiglobulin tests with anti\u2010IgG","volume":"37","author":"Richa E","year":"2007","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03192.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12219"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2008.12.003"},{"key":"e_1_2_6_13_1","first-page":"2501","article-title":"Successful clinical small\u2010bowel transplantation","volume":"22","author":"Deltz E","year":"1990","journal-title":"Transplant Proc"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12979"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21276"},{"key":"e_1_2_6_16_1","first-page":"163","article-title":"Life\u2010threatening autoimmune hemolytic anemia treated with manual whole blood exchange with rapid clinical improvement","volume":"4","author":"Cooling L","year":"2013","journal-title":"J Blood Disord Transfus"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.14086","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.14086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T19:55:23Z","timestamp":1695498923000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.14086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,28]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/trf.14086"],"URL":"https:\/\/doi.org\/10.1111\/trf.14086","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,28]]}}}