{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T08:31:07Z","timestamp":1771921867495,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T00:00:00Z","timestamp":1493078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["2 U01 CK000360\u201003"],"award-info":[{"award-number":["2 U01 CK000360\u201003"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Transfusion transmission of human prion diseases has been observed for variant Creutzfeldt\u2010Jakob disease (vCJD), but not for the classic forms of prion disease (CJD: sporadic, genetic, and iatrogenic). Although the presence of prions or misfolded prion proteins in blood has been documented in some patients with the most common form of CJD, sporadic CJD, no transfusion\u2010transmitted cases of CJD have been recognized. Since 1995, the American Red Cross has conducted a lookback study of the recipients of blood products from donors who develop CJD to assess the risk of blood\u2010borne CJD transmission in the United States.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>Blood donors subsequently diagnosed with confirmed or probable CJD were enrolled and the consignees were asked to identify the recipients of their blood products. These donors' transfusion recipients are traced annually with the National Death Index to see if they subsequently die of CJD.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>To date, 65 CJD donors have been enrolled along with 826 of their blood recipients. These recipients have contributed 3934 person\u2010years of follow\u2010up and no transfusion\u2010transmitted cases of CJD have been recognized.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>From this study, as well as other epidemiologic studies, there is no evidence of CJD transfusion transmission; this risk remains theoretical.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.14145","type":"journal-article","created":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T04:06:19Z","timestamp":1493179579000},"page":"1875-1878","source":"Crossref","is-referenced-by-count":36,"title":["Creutzfeldt\u2010Jakob disease lookback study: 21 years of surveillance for transfusion transmission risk"],"prefix":"10.1111","volume":"57","author":[{"given":"Lauren A.","family":"Crowder","sequence":"first","affiliation":[{"name":"Scientific Affairs, American Red Cross Rockville Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence B.","family":"Schonberger","sequence":"additional","affiliation":[{"name":"National Center for Emerging and Zoonotic Infectious Diseases, Division of High\u2010Consequence Pathogens and Pathology US Centers for Disease Control and Prevention Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger Y.","family":"Dodd","sequence":"additional","affiliation":[{"name":"American Red Cross, Medical Office Gaithersburg Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Whitney R.","family":"Steele","sequence":"additional","affiliation":[{"name":"Scientific Affairs, American Red Cross Rockville Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,25]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Creutzfeldt\u2010Jakob Disease Classic (CJD) [Internet]. Atlanta:Centers for Disease Control and Prevention;2015[cited 2016 Nov 9]. Available from:www.cdc.gov\/prions\/cjd"},{"key":"e_1_2_7_3_1","unstructured":"National Prion Disease Pathology Surveillance Center [Internet]. Cleveland (OH): Case Western Reserve University; c2010[cited 2016 Nov 16]. Available from:http:\/\/CJDsurveillance.com."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23589"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2006.00837.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12371"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2006.00833.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16811-6"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2007.09.003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.02056.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2001.130353"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.6001"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.03004.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03198.x"},{"key":"e_1_2_7_15_1","first-page":"67","article-title":"Survival of blood transfusion recipients identified by a look\u2010back investigation","volume":"12","author":"Dorsey KA","year":"2014","journal-title":"Blood Transfus"},{"key":"e_1_2_7_16_1","first-page":"629","volume-title":"Prion biology and diseases","author":"Will RG","year":"2004"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.14145","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.14145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T01:07:36Z","timestamp":1695517656000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.14145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,25]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/trf.14145"],"URL":"https:\/\/doi.org\/10.1111\/trf.14145","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,25]]}}}