{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:56:32Z","timestamp":1790060192540,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T00:00:00Z","timestamp":1498003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Individuals with the partial D phenotype when exposed to D+ red blood cells (RBCs) carrying the epitopes they lack may develop anti\u2010D specific for the missing epitopes. DNB is the most common partial D in Caucasians and the clinical significance for anti\u2010D in these individuals is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>This article describes the serologic genotyping results and clinical manifestations in two group D+ babies of a mother presenting as group O, D+ with alloanti\u2010D.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The mother was hemizygous for <jats:italic>RHD*DNB<\/jats:italic> gene and sequencing confirmed a single\u2010nucleotide change at c.1063G&gt;A. One baby (group A, D+) displayed bilirubinemia at birth with a normal hemoglobin level. Anti\u2010A and anti\u2010D were eluted from the RBCs. For the next ongoing pregnancy, the anti\u2010D titer increased from 32 to 256. On delivery the baby typed group O and anti\u2010D was eluted from the RBCs. This baby at birth exhibited anemia, reticulocytosis, and hyperbilirubinemia requiring intensive phototherapy treatment from Day 0 to Day\u00a09 after birth and was discharged on Day 13. Intravenous immunoglobulin was also administered. Both babies were heterozygous for <jats:italic>RHD<\/jats:italic> and <jats:italic>RHD*DNB<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The anti\u2010D produced by this woman with partial D DNB resulted in a case of hemolytic disease of the fetus and newborn (HDFN) requiring intensive treatment in the perinatal period. Anti\u2010D formed by women with the partial D DNB phenotype has the potential to cause HDFN where the fetus is D+. Women carrying <jats:italic>RHD*DNB<\/jats:italic> should be offered appropriate prophylactic anti\u2010D and be transfused with D\u2013 RBCs if not already alloimmunized.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.14156","type":"journal-article","created":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T03:49:44Z","timestamp":1498103384000},"page":"1938-1943","source":"Crossref","is-referenced-by-count":9,"title":["Anti\u2010D in a mother, hemizygous for the variant <i>RHD*DNB<\/i> gene, associated with hemolytic disease of the fetus and newborn"],"prefix":"10.1111","volume":"57","author":[{"given":"Kelli M.","family":"Quantock","sequence":"first","affiliation":[{"name":"Blood Bank Division Department of Pathology, Mater Health South Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8568-0604","authenticated-orcid":false,"given":"Genghis H.","family":"Lopez","sequence":"additional","affiliation":[{"name":"Research and Development, Clinical Services and Research Division, Australian Red Cross Blood Service Kelvin Grove Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine A.","family":"Hyland","sequence":"additional","affiliation":[{"name":"Research and Development, Clinical Services and Research Division, Australian Red Cross Blood Service Kelvin Grove Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yew\u2010Wah","family":"Liew","sequence":"additional","affiliation":[{"name":"Red Cell Reference Laboratory, Clinical Services and Research Division Australian Red Cross Blood Service Kelvin Grove Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Flower","sequence":"additional","affiliation":[{"name":"Research and Development, Clinical Services and Research Division, Australian Red Cross Blood Service Kelvin Grove Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans J.","family":"Niemann","sequence":"additional","affiliation":[{"name":"Blood Bank Division Department of Pathology, Mater Health South Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Joyce","sequence":"additional","affiliation":[{"name":"Blood Bank Division Department of Pathology, Mater Health South Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12275"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1054\/blre.1999.0123"},{"key":"e_1_2_9_4_1","first-page":"4","article-title":"The challenge and paradox in serology RhD typing for blood donors and patients","volume":"11","author":"Hyland CA.","year":"2013","journal-title":"Blood Transfus"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-03-0742"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1111\/trf.12145","article-title":"D category IV: a group of clinically relevant and phylogenetically diverse partial D","volume":"53","author":"von Zabern I","year":"2013","journal-title":"Transfusion"},{"key":"e_1_2_9_7_1","unstructured":"WagnerFF FlegelWA.Rhesus surveillance rhesus immunization registry base [Internet]. 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