{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:42:04Z","timestamp":1788478924596,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T00:00:00Z","timestamp":1496620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Anti\u2010D is a well\u2010documented, significant cause of hemolytic disease of the fetus and newborn (HDFN), but its presence in breast milk is not routinely described. Theoretically, breast milk containing anti\u2010D could have the potential to exacerbate HDFN if ingested by the affected infant.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>This is a case report of a 28\u2010week premature male neonate with hydrops fetalis born to a 32\u2010year\u2010old woman (gravidity 3\/parity 3) with anti\u2010D and anti\u2010G. The male neonate experienced prolonged HDFN due to passive acquisition of anti\u2010D in the mother's breast milk.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The mother's breast milk reacted strongly (4+) with the D\u2010positive cells in the antibody screen test. Discontinuation of breast milk feeding and addition of total parenteral nutrition led to the cessation of clinically significant HDFN.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Although anti\u2010D is a significant cause of HDFN through placental transfer of antibody, exacerbation of the condition through breast milk antibodies is rarely described. The current case highlights the possibility of this occurring. Discontinuation of maternal breast milk feedings should be considered in infants with HDFN who do not respond to standard treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.14171","type":"journal-article","created":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T05:26:46Z","timestamp":1496640406000},"page":"2121-2124","source":"Crossref","is-referenced-by-count":23,"title":["Persistent hemolytic disease of the fetus and newborn (HDFN) associated with passive acquisition of anti\u2010D in maternal breast milk"],"prefix":"10.1111","volume":"57","author":[{"given":"Marissa","family":"Li","sequence":"first","affiliation":[{"name":"Blood Systems, Inc Scottsdale Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Blaustein","sequence":"additional","affiliation":[{"name":"Santa Barbara Cottage Hospital Santa Barbara California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02534.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(03)00336-0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/bfm.2007.0024"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12387"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-12-614446"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.4490.138"},{"key":"e_1_2_6_8_1","first-page":"3336","article-title":"Hemolytic disease of the newborn due to iso\u2010immunization to the group A antigen; role of the agglutinins of milk","volume":"26","author":"Christiaens G.","year":"1950","journal-title":"Sem Hop"},{"key":"e_1_2_6_9_1","first-page":"421","article-title":"Studies on immune iso\u2010antibodies in human milk. Etiology of prolonged jaundice of newborn infants with the serological conflict of main groups","volume":"17","author":"Dzierzkowa\u2010Borodej W","year":"1962","journal-title":"Pol Tyq Lek"},{"key":"e_1_2_6_10_1","first-page":"58","article-title":"The importance to the newborn infant of determining the Rh antibodies of the mother's milk\u2014review of the literature","volume":"11","author":"Umbrumiants DV.","year":"1966","journal-title":"Vopr Okhr Materin Det"},{"key":"e_1_2_6_11_1","first-page":"1728","article-title":"Research on the passage of isohemaglutinins into milk in hemolytic disease of the newborn","volume":"19","author":"Lange MM","year":"1967","journal-title":"Minerva Pediatr"},{"key":"e_1_2_6_12_1","article-title":"Study of antibodies in female milk in women with feto\u2010maternal ABO blood incompatibility","volume":"46","author":"Wieczorek P.","year":"1975","journal-title":"Ginekol Pol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-83-6-865"}],"container-title":["Transfusion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftrf.14171","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/trf.14171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T13:52:45Z","timestamp":1695477165000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/trf.14171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,5]]},"references-count":12,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/trf.14171"],"URL":"https:\/\/doi.org\/10.1111\/trf.14171","archive":["Portico"],"relation":{},"ISSN":["0041-1132","1537-2995"],"issn-type":[{"value":"0041-1132","type":"print"},{"value":"1537-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,5]]}}}