{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T03:55:14Z","timestamp":1788753314781,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T00:00:00Z","timestamp":1499212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Lenalidomide is an immunomodulatory drug that is also currently used in transplant\u2010eligible patients with multiple myeloma. Previous studies have suggested a negative impact of lenalidomide on the mobilization of CD34<jats:sup>+<\/jats:sup> cells. No data are available regarding the more detailed composition of blood grafts after lenalidomide.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>In a multicenter, prospective study, we analyzed the mobilization of CD34<jats:sup>+<\/jats:sup> cells, graft cellular composition, and post\u2010transplant hematologic recovery in 26 patients with multiple myeloma after lenalidomide\u2010based induction and in 34 lenalidomide\u2010naive controls with multiple myeloma. All patients were mobilized with low\u2010dose cyclophosphamide plus granulocyte\u2010colony\u2013stimulating factor. The cellular composition of the grafts was analyzed from thawed, cryopreserved samples with flow cytometry. Graft function was evaluated by engraftment data and by complete blood counts until 12 months after the graft infusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Patients in the lenalidomide arm had lower median peak CD34<jats:sup>+<\/jats:sup> counts and approximately 40% lower CD34<jats:sup>+<\/jats:sup> cell yields from the first apheresis session, but these differences were not significant. The median total number of CD34<jats:sup>+<\/jats:sup> cells collected was comparable (6.4 vs. 7.5 \u00d7 10<jats:sup>6<\/jats:sup>\/kg). The number of apheresis sessions was higher in the lenalidomide group (2 vs. 1; p\u2009=\u20090.039). The blood graft composition was comparable between the groups. Hematologic recovery within 12 months post\u2010transplant did not differ between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Lenalidomide\u2010based induction seems to have an impact on the number of aphereses performed, but not on the total yields of the CD34<jats:sup>+<\/jats:sup> cells in the graft. Neither cellular composition of the grafts nor post\u2010transplant recovery was affected by the limited pre\u2010transplant exposure to lenalidomide.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.14220","type":"journal-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T04:26:39Z","timestamp":1499315199000},"page":"2366-2372","source":"Crossref","is-referenced-by-count":11,"title":["Impact of lenalidomide\u2010based induction therapy on the mobilization of CD34<sup>+<\/sup> cells, blood graft cellular composition, and post\u2010transplant recovery in myeloma patients: a prospective multicenter study"],"prefix":"10.1111","volume":"57","author":[{"given":"Anu","family":"Partanen","sequence":"first","affiliation":[{"name":"Department of Medicine Kuopio University Hospital Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaakko","family":"Valtola","sequence":"additional","affiliation":[{"name":"Department of Medicine Kuopio University Hospital 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Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esa","family":"Jantunen","sequence":"additional","affiliation":[{"name":"Department of Medicine Kuopio University Hospital Kuopio 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