{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T12:44:56Z","timestamp":1785329096284,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T00:00:00Z","timestamp":1500595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>Zika virus (ZIKV) is a mosquito\u2010borne flavivirus that is the focus of an ongoing pandemic. ZIKV is notable for its severe neurologic sequelae in babies born to infected mothers. High rates of subclinical infection, as evidenced by the finding of ZIKV RNA in asymptomatic donors, raise concerns of risk to the blood supply. To date, a total of four suspected cases of transfusion\u2010transmitted ZIKV have been reported (all in Brazil), none of which were associated with clinical infection in the transfusion recipients. In 2016, the US Food and Drug Administration issued a guidance mandating national blood donor screening for ZIKV in the United States. Five days after implementation of donor screening at our facility, we encountered a ZIKV\u2010positive donor. We provide a practical approach to donor, recipient, and blood product management in the setting of a positive donor ZIKV result. Such has been informed by the challenges we faced in the workup of a ZIKV\u2010reactive donation and recipient lookback.<\/jats:p>","DOI":"10.1111\/trf.14252","type":"journal-article","created":{"date-parts":[[2017,7,22]],"date-time":"2017-07-22T03:18:48Z","timestamp":1500693528000},"page":"2077-2083","source":"Crossref","is-referenced-by-count":11,"title":["How do we manage blood donors and recipients after a positive Zika screening result?"],"prefix":"10.1111","volume":"57","author":[{"given":"Alexandra","family":"Jimenez","sequence":"first","affiliation":[{"name":"New York Blood Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth H.","family":"Shaz","sequence":"additional","affiliation":[{"name":"New York Blood Center New York New York"},{"name":"Columbia University Medical Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra","family":"Kessler","sequence":"additional","affiliation":[{"name":"New York Blood Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan M.","family":"Bloch","sequence":"additional","affiliation":[{"name":"Johns Hopkins University Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,21]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"WHO Director\u2010General summarizes the outcome of the Emergency Committee regarding clusters of microcephaly and Guillain\u2010Barr\u00e9 syndrome [Internet]. 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Outbreak News Today. [Internet]. Tampa (FL): The Global Dispatch Inc.; 2015 Dec 18 [cited 2017 May 29]. Available from:http:\/\/outbreaknewstoday.com\/transfusion-associated-zika-virus-reported-in-brazil-76935\/."},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1607262"},{"key":"e_1_2_11_16_1","unstructured":"Hot Topic: Zika and its impact to transfusion. Orlando (FL): AABB Annual Meeting;2016."},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.00032-16"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2016.08.001"},{"key":"e_1_2_11_19_1","unstructured":"Revised recommendations for reducing the risk of Zika virus transmission by blood and blood components: guidance for industry [Internet]. Silver Spring (MD): U.S. Department of Health and Human Services Food and Drug Administration Center for Biologics Evaluation and Research; 2016 [cited 2017 Jun 7]. 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