{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T22:09:22Z","timestamp":1768255762960,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T00:00:00Z","timestamp":1502064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>The objective was to identify risk factors associated with blood transfusion in patients undergoing high\u2010order Cesarean delivery (CD).<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>This was a retrospective cohort study of patients undergoing third or more CD by a single maternal\u2010fetal medicine practice between 2005 and 2016. We compared risk factors between women who did and did not receive a red blood cell transfusion during the operation or before discharge. Repeat analysis was performed after excluding women with placenta previa.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 514 patients were included, 18 of whom (3.5%; 95% confidence interval [CI], 2.2%\u20105.5%) received a blood transfusion. Placenta previa was the most significant risk factor for transfusion (61.1% of patients who received a transfusion vs. 1% of patients who did not; p\u2009&lt;\u20090.001). Patients with a placenta previa had a 68.8% likelihood of requiring a blood transfusion. After women who had placenta previa were excluded, the incidence of blood transfusion was seven of 498 (1.4%; 95% CI, 0.7%\u20102.9%). Risk factors significantly associated with blood transfusion in the absence of previa were prophylactic anticoagulation during pregnancy and having labored. The incidence of transfusion in patients with no placenta previa, no anticoagulation, and no labor was 0.7% (95% CI, 0.3%\u20102.1%). Placenta previa was the most predictive risk factor for transfusion with a positive predictive value of 68.8% and a negative predictive value of 98.4%.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>In patients undergoing a third or more CD, only placenta previa, prophylactic anticoagulation during pregnancy, and having labored are independently associated with requiring a blood transfusion. These data can be used to guide physician ordering of prepared blood products preoperatively.<\/jats:p><\/jats:sec>","DOI":"10.1111\/trf.14274","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T05:08:28Z","timestamp":1502082508000},"page":"2752-2757","source":"Crossref","is-referenced-by-count":15,"title":["Risk factors for blood transfusion in patients undergoing high\u2010order Cesarean delivery"],"prefix":"10.1111","volume":"57","author":[{"given":"Jessica","family":"Spiegelman","sequence":"first","affiliation":[{"name":"Department of Obstetrics Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, PLLC New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirella","family":"Mourad","sequence":"additional","affiliation":[{"name":"Columbia University School of Medicine, PLLC New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Melka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, PLLC New York New York"},{"name":"Maternal Fetal Medicine Associates, PLLC New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simi","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, PLLC New York New York"},{"name":"Maternal Fetal Medicine Associates, PLLC New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Lam\u2010Rachlin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, PLLC New York New York"},{"name":"Maternal Fetal Medicine Associates, PLLC New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Rebarber","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, PLLC New York New York"},{"name":"Maternal Fetal Medicine Associates, PLLC New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel H.","family":"Saltzman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, PLLC New York New York"},{"name":"Maternal Fetal Medicine Associates, PLLC New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan S.","family":"Fox","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, PLLC New York New York"},{"name":"Maternal Fetal Medicine Associates, PLLC New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0000000000000328"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2005.12.013"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000054"},{"key":"e_1_2_6_5_1","unstructured":"MartinJA HamiltonBE OstermanMJ.Births in the United States 2014. 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